Machado Joseph Disease Type 4 C0686352
A rare hereditary nervous system disorder causing progressive movement problems, including poor coordination and involuntary movements. It typically runs in families and worsens over time. Treatment focuses on managing symptoms.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Progressive gait ataxia
(neurologic)Bradykinesia
(neurologic)Impaired vertical gaze
(neurologic)Dystonia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Balance and Coordination Training
Specialized physical therapy focusing on proprioceptive training, balance exercises, and coordination activities to slow functional decline.
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Neuropathic Pain Management
Gabapentin or pregabalin to address neuropathic pain components that commonly accompany spinocerebellar ataxias.
Additional treatment options
Occupational Therapy Assessment
Evaluation and training for activities of daily living, home modifications, and adaptive equipment recommendations.
complementarySupportive Counseling Services
Psychological support addressing the emotional impact of progressive neurological disease including family counseling and support groups.
psychologicalEnvironmental Safety Modifications
Home and work environment assessment with modifications including grab bars, ramps, and fall prevention strategies.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Machado Joseph Disease Type 4 C0686352?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy