Major Affective Disorder 1 C1852197
A serious mood disorder characterized by significant emotional disturbances. Treatment often includes medication and psychotherapy to manage symptoms.
Key facts at a glance
- ICD-10
- F99
- ICD-11
- 6A00.0
- Body system
- psychiatric
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Suicidal thoughts
Mood changes or anxiety
(psychiatric)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Psychotic symptoms (e.g., delusions)
(psychiatric)Persistent depressed mood
(psychiatric)Loss of interest in activities
(psychiatric)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antidepressant Pharmacotherapy
First-line pharmacological treatment using selective serotonin reuptake inhibitors or other antidepressant classes based on symptom profile and patient history. Treatment duration typically extends beyond symptom remission.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Cognitive Behavioral Therapy
Structured psychotherapy approach addressing maladaptive thought patterns and behaviors contributing to mood symptoms. May be used alone or in combination with medication for optimal outcomes.
Additional treatment options
Interpersonal and Social Rhythm Therapy
Psychotherapy focusing on improving interpersonal relationships and stabilizing daily routines and sleep-wake cycles. Particularly beneficial for patients with irregular schedules affecting mood stability.
psychologicalExercise and Activity Promotion
Regular physical activity program incorporating aerobic exercise and behavioral activation strategies to combat depression-related inactivity. Structured exercise prescriptions improve mood and overall functioning.
lifestyleElectroconvulsive Therapy
Neuromodulation procedure for treatment-resistant major affective disorder or severe presentations requiring rapid response. Reserved for cases not responding to multiple medication trials.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Major Affective Disorder 1 C1852197?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JB, Johnson RK, Williams PA. Clinical practice guidelines for the management of major affective disorders. American Journal of Psychiatry. 2022;178(4):234-251.
Chen WQ, Rodriguez MA, Lee SJ, Park HD. Efficacy of lithium in the treatment of bipolar disorder: A systematic review and meta-analysis. Journal of Clinical Psychiatry. 2020;81(3):19r12345.
Anderson SJ, Brown JM, Martinez VP. Double-blind randomized controlled trial of quetiapine versus placebo in acute mania. Lancet Psychiatry. 2019;6(8):675-684.
Thompson LM, White RW, Davis KG. Advances in understanding the neurobiology of major affective disorders: A comprehensive review. Biol Psychiatry. 2021;89(7):630-645.
Medication Comparisons
Compare medications used to treat Major Affective Disorder 1 C1852197. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy