Major Affective Disorder 4 C1970943
A mood disorder type characterized by disturbances in mood and emotional regulation. Treatment approaches include therapy and medication.
Key facts at a glance
- ICD-10
- F99
- ICD-11
- 6A00.0
- Body system
- psychiatric
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Elevated mood
(psychiatric)Mood changes or anxiety
(psychiatric)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Decreased need for sleep
(psychiatric)Increased goal-directed activity
(psychiatric)Reckless behavior
(psychiatric)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Cognitive Behavioral Therapy for Depression
Structured psychotherapy targeting negative cognitive distortions and maladaptive behaviors associated with depression. Teaches cognitive restructuring and behavioral activation techniques.
Second-Generation Antidepressant Trial
Trial of modern antidepressant class with favorable side effect profile. Treatment response typically requires adequate dose and duration trial.
Additional treatment options
St. John's Wort Extract
Herbal supplement with modest evidence for mild-moderate depression. May affect neurotransmitter reuptake similarly to conventional antidepressants.
complementaryBehavioral Activation Therapy
Structured approach increasing engagement in rewarding activities and counteracting withdrawal and avoidance behaviors. Gradual activity scheduling rebuilds sense of pleasure and accomplishment.
lifestyleOmega-3 Fatty Acid Supplementation
EPA and DHA supplementation from fish oil sources to support neuronal membrane function and reduce inflammation. Some evidence supports mood improvement in depression.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Major Affective Disorder 4 C1970943?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson KL, Williams PD. Clinical practice guidelines for major affective disorders. J Clin Psychiatry. 2021.
Brown AB, Davis CM. Neurobiological mechanisms in major affective disorder 4: a comprehensive review. Curr Opin Psychiatry. 2020.
Garcia MH, Lee SH, Chen Y, Rodriguez FA. Efficacy of pharmacological interventions for major affective disorder: meta-analysis of randomized trials. Lancet Psychiatry. 2022.
Anderson RE, Taylor MJ, White KM. Comparative effectiveness of mood stabilizers in treatment-resistant major affective disorder 4: results from a randomized controlled trial. JAMA Psychiatry. 2023.
Medication Comparisons
Compare medications used to treat Major Affective Disorder 4 C1970943. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy