Major Depressive Disorder 1 C1837929
Major depressive disorder is a mood condition causing persistent sadness and loss of interest in activities. It affects people of all ages and is commonly treated with therapy, medication, or both.
Key facts at a glance
- ICD-10
- F99
- ICD-11
- 6A00.0
- Body system
- psychiatric
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Suicidal ideation
Mood changes or anxiety
(psychiatric)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Depressed mood
(psychiatric)Anhedonia
(psychiatric)Fatigue
(psychiatric)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
SSRIs (Selective Serotonin Reuptake Inhibitors)
First-line pharmacotherapy using SSRI medications that increase serotonin levels in the brain. Treatment typically begins at low doses and gradually increases based on response and tolerability.
Cognitive Behavioral Therapy (CBT)
Evidence-based psychotherapy that helps patients identify and modify negative thought patterns and behaviors. Typically delivered in weekly sessions over 12-20 weeks with homework assignments between sessions.
Additional treatment options
Regular Physical Exercise
Structured aerobic exercise program of moderate intensity for 30-45 minutes most days of the week. Exercise promotes neuroplasticity and endorphin release, which can improve mood and energy levels.
lifestyleMediterranean-Style Diet
Anti-inflammatory dietary pattern emphasizing fruits, vegetables, whole grains, lean proteins, and omega-3 fatty acids. Nutritional interventions support neurotransmitter synthesis and reduce inflammation associated with depression.
dietaryRegular Symptom Monitoring
Scheduled assessment using validated depression rating scales to track symptom severity and treatment response. Enables timely adjustments to treatment plans and early identification of relapse indicators.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Major Depressive Disorder 1 C1837929?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder. Am J Psychiatry. 2021.
Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and meta-analysis. Lancet. 2018.
Krystal AD, Pizzagalli DA, Smoski MJ, et al. Major depressive disorder: translating disease understanding into targeted treatment. Biol Psychiatry. 2020.
Trivedi MH, Rush AJ, Wisniewski SR, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry. 2006.
Medication Comparisons
Compare medications used to treat Major Depressive Disorder 1 C1837929. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy