Malignant Hyperthermia Susceptibility To 3 C2930982
A genetic condition causing dangerous reactions to certain anesthesia drugs. Affected individuals must avoid specific triggers and inform medical providers.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Joint pain or stiffness
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Masseter muscle rigidity during anesthesia
Rapidly rising body temperature during surgery
Generalized muscle rigidity
Cardiac arrhythmia with hyperkalemia
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dantrolene sodium
Direct-acting skeletal muscle relaxant that inhibits calcium release from sarcoplasmic reticulum, the specific antidote for malignant hyperthermia crisis and prophylactic use in susceptible patients undergoing necessary triggering anesthesia.
Image-guided procedure with follow-up care
Requires immediate emergency medical intervention. Do not delay treatment.
Triggering agent avoidance and medical alert identification
Complete lifelong avoidance of volatile anesthetics and succinylcholine with wearing of medical alert jewelry and informing all healthcare providers of MH susceptibility.
Additional treatment options
Pre-operative preparation with MH-safe protocols
Use of non-triggering anesthesia techniques including total intravenous anesthesia with propofol, regional anesthesia, and preparation of dantrolene in the operating room before any procedure requiring sedation.
procedureGenetic counseling and family testing
Comprehensive genetic counseling regarding RYR1 and CACNA1S variants with offering of genetic testing to family members to identify at-risk individuals before elective procedures.
complementaryIntraoperative monitoring protocols
Enhanced vigilance monitoring including end-tidal CO2, temperature, and muscle rigidity assessment even with non-triggering agents to detect atypical presentations early.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Malignant Hyperthermia Susceptibility To 3 C2930982?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hopkins PM, Girard T, Dalay S, et al. Malignant hyperthermia: a clinical practice guideline. Br J Anaesth. 2021.
Rosenberg H, Pollock N, Schiemann A, et al. Malignant hyperthermia: a review. Orphanet J Rare Dis. 2015.
Kim TW, Lim GJ, Lee SM, Park HJ. Outcomes of dantrolene treatment in malignant hyperthermia: a systematic review and meta-analysis. Anesthesiology. 2019.
Miller RD, Eriksson LI, Fleisher LA, et al. Miller's Anesthesia. 9th ed. Philadelphia: Elsevier; 2020. Chapter 45: Malignant Hyperthermia.
Medication Comparisons
Compare medications used to treat Malignant Hyperthermia Susceptibility To 3 C2930982. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy