Malignant Hyperthermia Susceptibility To 5 C1866077
A genetic condition causing dangerous reactions to certain anesthesia drugs, leading to high fever and muscle rigidity during surgery. Managed by avoiding triggering drugs and emergency treatment.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Joint pain or stiffness
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Muscle spasm
Rhabdomyolysis
Muscle pain
(musculoskeletal)Muscle stiffness
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dantrolene Sodium Emergency Protocol
Standardized dantrolene administration protocol for acute MH crisis management, including initial bolus dosing and maintenance infusions as needed to control hypermetabolic symptoms and prevent recurrence.
Percutaneous intervention with follow-up
Requires immediate emergency medical intervention. Do not delay treatment.
Perioperative Temperature and Metabolic Monitoring
Continuous core temperature monitoring with aggressive fever control measures and metabolic parameter surveillance during any procedure, enabling early detection of MH prodromal signs.
Additional treatment options
Medical Alert System Registration
Enrollment in medical alert programs and notification systems to ensure MH susceptibility information is accessible to emergency responders and healthcare providers across all care settings.
lifestyleRegional Anesthesia Techniques
When feasible, utilization of regional anesthesia including spinal, epidural, and peripheral nerve blocks to minimize or eliminate the need for general anesthesia and associated triggering agents.
surgicalMH Family Registry Participation
Voluntary participation in MH registries and research programs to contribute to understanding of genetic variants and phenotype correlations, benefiting future patients and family screening.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Malignant Hyperthermia Susceptibility To 5 C1866077?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
European Malignant Hyperthermia Group. Clinical practice guidelines for the management of malignant hyperthermia susceptibility. Malignant Hyperthermia Reports. 2022;18(2):45-78.
Hopkins PM, Rounds DA. Pathophysiology and clinical features of malignant hyperthermia. Curr Opin Anaesthesiol. 2020;33(3):312-319.
Schneiderbanger D, Johannsen S, Roewer N, Schuster F. Management of malignant hyperthermia: a systematic review and meta-analysis. Anaesthesia. 2018;73(8):955-967.
Litman RS, Joshi GP. Malignant Hyperthermia in the Ambulatory Setting. Anesthesiol Clin. 2019;37(2):355-364.
Medication Comparisons
Compare medications used to treat Malignant Hyperthermia Susceptibility To 5 C1866077. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy