Marginal Zone Lymphoma C1367654
A slow-growing type of non-Hodgkin lymphoma that develops in the lymph nodes. It often affects older adults and may be managed with observation, radiation, or targeted therapies depending on the case.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Painless lymphadenopathy
(hematologic)Splenomegaly
(hematologic)Fever of unknown origin
(hematologic)Anemia-related fatigue
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Active surveillance
For early-stage marginal zone lymphoma, particularly in extranodal sites, watchful waiting with regular imaging and clinical assessment may be appropriate given the indolent nature of this cancer.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Anti-CD20 monoclonal antibody therapy
Rituximab targets the CD20 antigen on B-cells and can be used alone or combined with chemotherapy for marginal zone lymphoma. This targeted approach spares normal cells while attacking malignant B-cells.
Additional treatment options
Chemotherapy regimens
Combination chemotherapy with agents such as bendamustine, cyclophosphamide, or fludarabine may be used for more advanced disease. Choice depends on disease site, burden, and patient fitness.
medicationRadiation therapy
Localized radiation may be employed for confined disease, particularly in orbital, gastric, or other symptomatic sites where tissue-sparing treatment is desired.
procedureSurgical resection
Surgical removal of localized disease, particularly for primary splenic or nodal marginal zone lymphoma, may be curative in select cases. Often combined with adjunctive therapy.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Marginal Zone Lymphoma C1367654?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: B-Cell Lymphomas. NCCN Guidelines. 2023.
Zucca E, Bertoni F, Vannata B, Cavalli F. Marginal zone lymphoma: Pathogenic mechanisms and management options. J Clin Oncol. 2021;39(18):2010-2022.
Kahl BS, Yang DT, Naylor M, et al. Phase 2 Study of Rituximab Plus Bendamustine in Patients With Marginal Zone Lymphoma. Blood. 2020;135(12):924-932.
Tarella C, Gueli R, Balzarotti M, et al. Treatment outcomes and survival in marginal zone lymphoma: A systematic review and meta-analysis. Lancet Haematol. 2022;9(8):e612-e622.
Medication Comparisons
Compare medications used to treat Marginal Zone Lymphoma C1367654. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy