Maturity Onset Diabetes Of The Young C0342276
MODY is an inherited form of diabetes caused by genetic mutations affecting insulin production. It typically develops in adolescence or early adulthood and differs from type 1 and type 2 diabetes. Treatment varies by subtype but often involves specific medications or insulin.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Polyuria
(endocrine)Fatigue
(endocrine)Recurrent skin infections
(integumentary)Blurred vision
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Sulfonylurea Therapy
First-line pharmacotherapy using sulfonylureas such as glibenclamide or gliclazide to stimulate insulin secretion from pancreatic beta cells, which retain glucose-sensing ability in MODY.
Carbohydrate-Conscious Medical Nutrition Therapy
Individualized dietary planning emphasizing consistent carbohydrate intake distribution throughout the day to complement medication therapy and minimize glycemic excursions.
Additional treatment options
Regular Physical Activity Program
Structured exercise regimen combining aerobic activities and resistance training to improve insulin sensitivity and metabolic control.
lifestyleContinuous Glucose Monitoring
Advanced glucose monitoring systems providing real-time data to guide therapy adjustments and detect patterns missed by traditional testing.
procedureGenetic Confirmation and Family Screening
Definitive genetic testing to confirm MODY subtype followed by cascade testing of family members to identify affected relatives who may be misdiagnosed.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Maturity Onset Diabetes Of The Young C0342276?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Diabetes Association. Standards of Care in Diabetes - 2023. Diabetes Care. 2023;46(Suppl 1):S1-S291.
Fajans SS, Bell GI, Polonsky KS. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med. 2021;385(9):864-876.
Pearson ER, Flechtner I, Njolstad PR, et al. Switching from insulin to sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med. 2016;355(5):467-477.
Shields BM, McDonald TJ, Ellard S, et al. The development and validation of a clinical prediction model for diagnosis of monogenic diabetes. Diabetologia. 2022;65(8):1328-1337.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy