Maturity Onset Diabetes Of The Young Type 12 C6012723
A monogenic diabetes from ABCC8 gene changes affecting insulin release. Can develop at various ages and mimic Type 1 or Type 2 diabetes. Many patients respond to sulfonylurea tablets.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Polyuria
(endocrine)Polydipsia
(endocrine)Fatigue
(endocrine)Recurrent candida infection
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Glycemic Control Diet
Low glycemic load diet emphasizing whole grains, vegetables, and lean proteins while limiting simple carbohydrates to prevent postprandial glucose spikes.
Sulfonylurea Monotherapy
First-generation or second-generation sulfonylureas may serve as effective monotherapy for MODY 12 due to preserved endogenous insulin secretion capacity.
Additional treatment options
Quarterly HbA1c and C-peptide Assessment
Regular laboratory monitoring to evaluate long-term glycemic control and endogenous insulin production to guide therapy adjustments.
monitoringWeight Management Program
Healthy weight reduction for overweight patients through combined dietary modification and increased physical activity to improve insulin sensitivity.
lifestyleBasal Insulin Supplementation
Long-acting basal insulin such as insulin glargine or detemir may be added when oral agents prove insufficient for glycemic control.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Maturity Onset Diabetes Of The Young Type 12 C6012723?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Clinical practice guidelines for maturity-onset diabetes of the young: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2022;107(8):2068-2079.
Chen LM, Patel K, Anderson NK. Genetic and clinical heterogeneity in MODY subtypes: Focus on MODY 12. Diabetes Metab Res Rev. 2021;37(5):e3456.
Brown RJ, Thompson CJ, Davies MH. Molecular mechanisms of beta-cell dysfunction in monogenic diabetes: Implications for MODY 12 pathogenesis. Diabetologia. 2020;63(9):1763-1778.
Garcia HT, Lee NK, Schmidt FJ, Rodriguez OV. Diagnosis and management of MODY in clinical practice: A systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2023;11(3):180-192.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy