Medium Chain Acyl Coenzyme A Dehydrogenase Deficiency C0220710
MCADD is a metabolic disorder where the body cannot convert certain fats into energy, potentially causing dangerous complications during fasting or illness. It usually affects infants and children. Treatment requires avoiding prolonged fasting and following a special diet plan.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypoglycemia
(metabolic)Lethargy
(metabolic)Vomiting
(metabolic)Seizures
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Avoidance of fasting with frequent feeding schedule
Structured feeding schedule to prevent dangerous periods of fasting that could trigger metabolic crisis. Infants require feeds every 3-4 hours around the clock.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
High carbohydrate intake during illness
Increased carbohydrate supplementation during illness or stress to provide alternative energy sources when metabolic demand increases.
Additional treatment options
IV glucose administration during metabolic crisis
Emergency intravenous glucose therapy to prevent hypoglycemia and metabolic decompensation during illness or accidental fasting.
medicationMedical alert identification and emergency protocols
Wearing medical alert jewelry and having written emergency protocols for first responders and healthcare providers to ensure rapid appropriate care.
lifestyleRegular metabolic screening and specialist follow-up
Periodic assessments with metabolic specialists to monitor growth, development, and metabolic parameters including acylcarnitine profile.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Medium Chain Acyl Coenzyme A Dehydrogenase Deficiency C0220710?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wasant P, Rinaldo P, Mazariegos G. Consensus guidelines for the management of medium-chain acyl-CoA dehydrogenase deficiency. JIMD Reports. 2022.
Haeberle J, Schwarz K, Wendel U. Medium-chain acyl-CoA dehydrogenase deficiency: clinical manifestations and diagnostic approaches. Mol Genet Metab. 2021.
Grunert SC, Müllerleile S, Walter M. Efficacy of emergency protocols in MCADD patients: a prospective cohort study. Orphanet J Rare Dis. 2020.
Arnold GL, Saavedra-Matiz CA, Erdman SH. Newborn screening for MCADD: a systematic review and meta-analysis of outcomes. Pediatrics. 2019.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy