Mendez Johnson Immunoneurologic Syndrome Cn381633
A rare syndrome affecting the nervous and immune systems, causing developmental delays and immune abnormalities. The outlook varies based on symptoms. Multidisciplinary care addresses neurological and immunological needs.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Autoimmune encephalitis
Severe epilepsy
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent infections
(immunologic)Neurologic developmental delay
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Intravenous immunoglobulin (IVIG) therapy to address immune deficiencies commonly associated with immunoneurologic syndromes, providing passive immunity and modulating immune function.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Neuromuscular Rehabilitation
Specialized physical therapy program targeting motor function, balance, and coordination deficits common in immunoneurologic conditions to maintain mobility and prevent contractures.
Additional treatment options
Comprehensive Immunologic and Neurologic Monitoring
Regular assessment of immune function parameters, neurologic status, and disease progression through laboratory studies and clinical examinations.
monitoringImmunomodulatory Therapy
Use of corticosteroids or other immunomodulatory agents to manage autoimmune components and inflammatory manifestations of the syndrome.
medicationInfection Prevention Strategies
Implementation of preventive measures including hygiene protocols, vaccination planning, and avoidance of infectious exposures to reduce morbidity from infections.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Mendez Johnson Immunoneurologic Syndrome Cn381633?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Mendez Johnson Immunoneurologic Syndrome Cn381633. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy