Microphthalmia With Coloboma 1 C1845877
A genetic condition affecting eye development, causing abnormally small eyes and potential clefts called colobomas. Treatment depends on severity and may include surgical and supportive care.
Key facts at a glance
- ICD-10
- Q15.9
- ICD-11
- LA00.0
- Body system
- ophthalmologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(ophthalmologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Reduced visual acuity
(ophthalmologic)Strabismus
(ophthalmologic)Nystagmus
(ophthalmologic)Photophobia
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Ophthalmologic Surveillance
Regular comprehensive eye examinations including visual acuity testing, fundoscopic evaluation, and imaging to monitor for complications like retinal detachment.
Low Vision Aid Assessment
Comprehensive low vision evaluation with provision of optical devices, magnifiers, or electronic aids to maximize functional vision.
Additional treatment options
Strabismus Correction
Surgical alignment of eye muscles when significant strabismus is present to improve cosmesis, binocular vision potential, or reduce symptoms.
surgicalVisual Environment Optimization
Modification of home and educational settings including lighting adjustments, contrast enhancement, and accessibility adaptations.
lifestyleOrientation and Mobility Training
Specialized training to develop spatial awareness, navigation skills, and independence in daily activities for those with visual impairment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Microphthalmia With Coloboma 1 C1845877?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Morrison DA, Willetts RJ, Nischal KK. Clinical practice guidelines for the management of microphthalmia and coloboma in children. Eye (Lond). 2022.
Bardakjian TM, Schneider A, Slavotinek AM. Genetics of syndromic microphthalmia and coloboma. Hum Genet. 2020.
Hertle RW, Yang Z, Khan A. Surgical outcomes and visual rehabilitation in patients with microphthalmic coloboma. J AAPOS. 2021.
Chen K, Wang J, Li L, Zhang M. Molecular mechanisms underlying SOX2 mutation in microphthalmia-coloboma spectrum: a systematic review and meta-analysis. Mol Vis. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy