Mixed Phenotype Acute Leukemia T Myeloid Cn372142
A hybrid blood cancer with T-cell and myeloid features, affecting children and adults. Treatment includes intensive chemotherapy and stem cell transplant, with serious prognosis.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Severe headache
Fatigue
(hematologic)Mucosal bleeding
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Acute lymphoblastic leukemia-style chemotherapy
High-intensity multi-drug chemotherapy protocol designed for mixed phenotype acute leukemia, incorporating steroids, vinca alkaloids, and anthracyclines to achieve morphological remission.
Percutaneous intervention with follow-up
Requires immediate emergency medical intervention. Do not delay treatment.
Consolidation with allogeneic stem cell transplant
Following successful induction, stem cell transplantation from a compatible donor provides potentially curative therapy for this aggressive hematologic malignancy.
Additional treatment options
Monoclonal antibody therapy
Antibody-based treatments targeting specific cell surface antigens expressed on leukemic blasts may be incorporated into treatment protocols for enhanced disease control.
medicationMinimal residual disease monitoring
Highly sensitive flow cytometry or molecular testing to detect residual leukemia cells below morphological detection threshold, guiding treatment intensity decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Mixed Phenotype Acute Leukemia T Myeloid Cn372142?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2022.
Matutes E, Pickl WF, Van't Veer M, et al. Mixed-phenotype acute leukemia: clinical and laboratory features and treatment outcomes. Blood. 2021;137(18):2461-2470.
Hrusak O, de Haas V, Stancikova J, et al. International cooperative study identifies treatment strategy for childhood mixed phenotype acute leukemia. J Clin Oncol. 2019;37(12):994-1006.
Weinberg OK, Arber DA. Mixed phenotype acute leukemia: a historical perspective and contemporary approach to diagnosis. Haematologica. 2020;105(7):1812-1822.
Medication Comparisons
Compare medications used to treat Mixed Phenotype Acute Leukemia T Myeloid Cn372142. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy