Mixed Phenotype Acute Leukemia T Myeloid Not Otherwise Specified C2826055
A rare blood cancer where leukemic cells show both T-cell and myeloid characteristics, affecting children and adults. Treated with intensive chemotherapy and stem cell transplant, with serious prognosis.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Severe headache
Fatigue
(hematologic)Mucosal bleeding
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Multi-agent chemotherapy regimen
Intensive combination chemotherapy based on acute lymphoblastic leukemia (ALL) protocols, typically including vincristine, corticosteroids, and cyclophosphamide to induce remission in this aggressive leukemia.
Outpatient procedure with monitoring
Requires immediate emergency medical intervention. Do not delay treatment.
Allogeneic hematopoietic stem cell transplantation
After achieving remission with chemotherapy, consolidation with stem cell transplant from a matched donor provides the best chance for durable remission in this high-risk leukemia.
Additional treatment options
Targeted therapy with tyrosine kinase inhibitors
For cases with specific genetic markers, targeted agents may be added to standard chemotherapy to improve response rates and reduce relapse risk.
medicationIntensive laboratory and imaging surveillance
Frequent complete blood counts, bone marrow biopsies, and imaging studies to assess treatment response, detect minimal residual disease, and identify complications early.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Mixed Phenotype Acute Leukemia T Myeloid Not Otherwise Specified C2826055?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Alpermann AM, Schnittger S, Kern W, et al. Diagnosis and Treatment of Mixed Phenotype Acute Leukemia: ELN Recommendations. Blood. 2021.
Wolach O, Stone RM. Mixed Phenotype Acute Leukemia: Current Concepts and Future Directions. Leukemia. 2020.
Shimony S, Zahran D, Horowitz NA, et al. Treatment Outcomes of Mixed Phenotype Acute Leukemia: A Retrospective Analysis. Haematologica. 2022.
Mrózek K, Carroll AJ, Raimondi SC, et al. Immunophenotypic Classification and Clinical Features of Mixed Phenotype Acute Leukemia. J Clin Oncol. 2019.
Medication Comparisons
Compare medications used to treat Mixed Phenotype Acute Leukemia T Myeloid Not Otherwise Specified C2826055. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy