Mixed Phenotype Acute Leukemia With T V 11q23 3 C2826048
A rare, aggressive blood cancer with mixed cell features and KMT2A gene rearrangements. Requires intensive chemotherapy and often stem cell transplantation for potential cure.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Severe headache
Fatigue
(hematologic)Mucosal bleeding
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Acute lymphoblastic leukemia-style induction
Intensive multi-agent chemotherapy regimen combining alkylators, antimetabolites, and topoisomerase inhibitors targeting both myeloid and lymphoid blast populations characteristic of KMT2A-rearranged leukemia.
Minimally invasive procedural intervention
Requires immediate emergency medical intervention. Do not delay treatment.
Allogeneic stem cell transplantation
Curative-intent hematopoietic stem cell transplantation following achievement of complete remission. Particularly important in KMT2A-rearranged cases given high relapse rates with chemotherapy alone.
Additional treatment options
Epipodophyllotoxin-based consolidation
Continued chemotherapy using epipodophyllotoxins and other agents effective against KMT2A-rearranged leukemias. May include high-dose cytarabine and anthracyclines.
medicationMolecular relapse monitoring
KMT2A rearrangement-specific PCR monitoring to detect molecular relapse before hematologic recurrence. Regular bone marrow assessments with sensitivity detection.
monitoringSupportive care and infection prophylaxis
Aggressive management of neutropenia, anemia, and thrombocytopenia with transfusions and growth factors. Antimicrobial prophylaxis during intensive chemotherapy phases.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Mixed Phenotype Acute Leukemia With T V 11q23 3 C2826048?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias. Blood. 2022.
Weinberg OK, Arber DA. Mixed phenotype acute leukemia: a clinical and pathologic review. Am J Clin Pathol. 2020.
Mannelli F, Gianfaldoni G, Intermesoli T, et al. Treatment of Mixed Phenotype Acute Leukemia: A Multicenter Retrospective Study. Haematologica. 2021.
Liu YR, Xu LP, Zhang XH. Mixed phenotype acute leukemia with KMT2A rearrangements: Current understanding and future perspectives. Leuk Res. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy