Multiple Endocrine Neoplasia Type 2a C0025268
A hereditary syndrome causing tumors in endocrine glands, particularly thyroid and adrenal glands. Requires lifelong monitoring and often prophylactic surgery to reduce cancer risk.
Key facts at a glance
- ICD-10
- E31.21
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic Thyroidectomy
Preventive surgical removal of the thyroid gland before medullary thyroid carcinoma develops, guided by genetic testing results and calcitonin levels. This is the primary intervention for MEN2A and is typically performed early based on specific mutations.
Comprehensive Screening Protocol
Lifelong surveillance program including annual calcitonin and CEA testing, periodic screening for pheochromocytoma with plasma free metanephrines, and calcium studies for parathyroid involvement.
Additional treatment options
Tyrosine Kinase Inhibitor Therapy
Targeted therapy using tyrosine kinase inhibitors for advanced medullary thyroid carcinoma that is unresectable or metastatic. These agents target pathways involved in tumor progression.
medicationAdrenalectomy for Pheochromocytoma
Surgical removal of pheochromocytoma when detected, typically performed using minimally invasive techniques. Adrenal-sparing approaches may be considered in bilateral cases to preserve adrenal function.
surgicalGenetic Counseling and Family Screening
Comprehensive genetic counseling for affected individuals and at-risk family members, including discussion of inheritance patterns, reproductive options, and the importance of cascade testing for all first-degree relatives.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Multiple Endocrine Neoplasia Type 2a C0025268?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Multiple Endocrine Neoplasia Type 2a C0025268. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy