Multiple Endocrine Neoplasia Type 2b C0025269
A hereditary cancer syndrome causing endocrine tumors along with distinctive physical features. Early detection and proactive treatment are essential due to aggressive tumor growth.
Key facts at a glance
- ICD-10
- E31.21
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic Thyroidectomy
Surgical removal of the thyroid gland to prevent medullary thyroid carcinoma, which is nearly inevitable in MEN2B. Early intervention before tumor development significantly improves survival outcomes.
Adrenalectomy for Pheochromocytoma
Surgical removal of adrenal tumors that secrete excess catecholamines. Requires careful preoperative preparation with alpha-blockade to prevent hypertensive crisis during surgery.
Additional treatment options
Regular Biochemical Screening
Comprehensive monitoring including serum calcitonin, metanephrines, and imaging studies to detect tumors at early stages when treatment is most effective.
monitoringTyrosine Kinase Inhibitor Therapy
Targeted therapy for advanced or metastatic medullary thyroid carcinoma. These agents inhibit signaling pathways that promote tumor growth and spread.
medicationGenetic Counseling and Psychological Support
Comprehensive counseling for patients and families regarding the hereditary nature of MEN2B, including discussion of screening implications for family members and psychosocial adaptation to chronic illness.
psychologicalMedication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy