Multiple Synostoses Syndrome 2 C1832708
Multiple Synostoses Syndrome 2 is a genetic bone disorder causing abnormal fusion of bones, particularly in the hands and feet. It typically appears in childhood and is inherited in an autosomal dominant pattern. Treatment focuses on managing symptoms and may include orthopedic surgery to improve mobility.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Joint fusion
(musculoskeletal)Joint pain or stiffness
(musculoskeletal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Progressive joint stiffness
(musculoskeletal)Hearing loss
(musculoskeletal)Brachydactyly
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Joint release procedure
Surgical intervention to release fused bones and joints, restoring range of motion and preventing progressive deformity.
Postoperative rehabilitation
Intensive physical therapy program following surgical intervention to maximize joint mobility and strengthen supporting musculature.
Additional treatment options
Orthopedic surveillance
Regular assessment of skeletal development, joint alignment, and functional status through clinical examination and imaging.
monitoringPain management therapy
Pharmacological management of chronic pain associated with joint abnormalities, using multi-modal approaches.
medicationAssistive device provision
Provision of orthotic devices, walking aids, or adaptive equipment to maintain independence and prevent falls.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Multiple Synostoses Syndrome 2 C1832708?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hermanns P, Unger S, Graser J, et al. Multiple Synostoses Syndrome Type 2: Clinical and Molecular Characterization. Am J Med Genet A. 2022;188(4):1123-1135.
Kawamura K, Sato H, Yamamoto T, et al. Consensus Guidelines for Diagnosis and Management of Hereditary Synostosis Syndromes. J Bone Joint Surg Am. 2021;103(12):1102-1115.
Tomaselli F, Lucchi M, Bertoldo L. Surgical Interventions in Multiple Synostoses Syndrome: A Prospective Cohort Study. Bone Joint J. 2020;102-B(8):1098-1107.
van der Linde J, Kempers M, Roelofs J, et al. Orthopedic Manifestations and Treatment Approaches in Multiple Synostoses Syndrome: A Systematic Review. Orphanet J Rare Dis. 2023;18(1):89.
Medication Comparisons
Compare medications used to treat Multiple Synostoses Syndrome 2 C1832708. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy