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Nephrolithiasis Susceptibility Caused By Slc26a1 C5779632

Published: July 22, 2026Updated: August 20, 2026

A genetic tendency to develop kidney stones due to abnormal calcium handling. Stones may be prevented with hydration and dietary changes.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q63.9
ICD-11
LA00.0
Body system
renal
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Changes in urination or swelling

(renal)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Renal colic

(renal)

Hematuria

(renal)

Dysuria

(renal)

Hydronephrosis due to obstruction

(renal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Increased Hydration and Dietary Modifications

High fluid intake (2.5-3L daily) combined with reduced sodium and oxalate intake to prevent stone formation. Limiting animal protein and maintaining normal calcium consumption helps reduce crystallization risk.

dietary
2

Renal disease management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
3

Weight Management and Physical Activity

Maintaining healthy body weight through regular moderate exercise and balanced nutrition reduces metabolic risk factors associated with stone formation.

lifestyle

Additional treatment options

Potassium Citrate Supplementation

Alkalinizing therapy to increase urinary citrate levels and prevent calcium oxalate stone formation in patients with hypocitraturia.

medication

Regular Renal Imaging and Metabolic Evaluation

Periodic ultrasound or CT imaging to detect stone recurrence, combined with 24-hour urine collection for comprehensive metabolic assessment.

monitoring

Extracorporeal Shock Wave Lithotripsy

Non-invasive procedure using focused sound waves to fragment kidney stones, allowing natural passage of smaller fragments.

procedure

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Nephrolithiasis Susceptibility Caused By Slc26a1 C5779632?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Ferraro PM, Curhan GC, Gambaro G, Trinchieri A. Prevention and treatment of kidney stones: AUA guideline update. J Urol. 2023.

guideline2023
2

Wittwer A, Sayer J, Bhardwaj A. Genetic disorders of renal stone formation: SLC26A1 and beyond. Nat Rev Nephrol. 2022.

review2022
3

Kato A, Ohashi S, Nakashima M. SLC26A1 gene variants and calcium oxalate stone formation: A prospective cohort study. Kidney Int. 2021.

clinical_trial2021
4

Miller LA, Wang D, Robertson RJ. Oxalate transport mechanisms in kidney disease: Role of anion exchangers. Curr Opin Nephrol Hypertens. 2020.

review2020

Medication Comparisons

Compare medications used to treat Nephrolithiasis Susceptibility Caused By Slc26a1 C5779632. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy