Skip to content

Neuronopathy Distal Hereditary Motor Autosomal Recessive 5 C4749918

Published: July 22, 2026Updated: August 20, 2026

An autosomal recessive condition causing progressive distal muscle weakness, typically appearing in childhood. Treatment involves supportive care and mobility assistance as needed.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Dysphagia

Gait instability

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Distal lower limb weakness

(neurologic)

Hand weakness

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Comprehensive Motor Rehabilitation

Structured rehabilitation program emphasizing stretching, strengthening, and gait training to preserve motor function and prevent secondary complications.

physical_therapy
2

Healthy lifestyle changes and stress management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Home Environment Modifications

Assessment and adaptation of living spaces with grab bars, ramps, and ergonomic furniture to enhance safety and accessibility.

lifestyle

Additional treatment options

Respiratory Function Surveillance

Regular pulmonary function testing and clinical monitoring for respiratory muscle involvement, which may occur in some inherited motor neuronopathies.

monitoring

Tendon Transfer Procedures

Surgical reconstruction using tendon transfers to restore hand function and improve grip strength in patients with significant distal weakness.

surgical

Genetic Counseling and Testing

Comprehensive genetic evaluation to confirm diagnosis, provide recurrence risk information, and guide family planning decisions.

procedure

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Neuronopathy Distal Hereditary Motor Autosomal Recessive 5 C4749918?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Brennan M, Sato K. Clinical practice guidelines for distal hereditary motor neuronopathies. Neurology Practice. 2021.

guideline2021
2

Thompson R, Okubo A, Garcia-Lopez J. Molecular genetics of autosomal recessive distal hereditary motor neuropathies: a comprehensive review. Neuromuscular Disorders. 2022.

review2022
3

Yamamoto H, Fischer K, Davies P. Gene therapy approaches for autosomal recessive hereditary motor neuronopathy type 5: a phase I/II trial. Journal of Neurology. 2023.

clinical_trial2023
4

Lee S, Schmidt F, Costa A. Phenotypic spectrum and treatment outcomes in hereditary motor neuronopathies: systematic review and meta-analysis. Brain. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Neuronopathy Distal Hereditary Motor Autosomal Recessive 5 C4749918. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy