Neuronopathy Distal Hereditary Motor Type 5c C5436838
A genetic condition affecting motor neurons that leads to gradual muscle weakness, usually starting in the distal limbs. Both genders can be affected depending on inheritance pattern. Treatment involves supportive measures like physical therapy and adaptive equipment.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal lower limb weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hand weakness
(neurologic)Loss of finger dexterity
(neurologic)Muscle cramping
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Customized Physical Therapy Program
A supervised exercise program focusing on maintaining muscle strength, improving balance, and preventing contractures through targeted stretching and resistance training.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Regular Neurological Monitoring
Periodic assessment of motor function, muscle strength, and disease progression through clinical examinations and functional scales.
Additional treatment options
Assistive Device Assessment
Evaluation for and provision of appropriate assistive devices such as ankle-foot orthotics, walking aids, or adaptive equipment to maintain mobility and independence.
lifestylePsychological Support Services
Counseling and support services to address the emotional and psychological impact of living with a progressive neuromuscular condition.
psychologicalOccupational Therapy Consultation
Assessment and training for activities of daily living, home modifications, and strategies to maintain functional independence.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Neuronopathy Distal Hereditary Motor Type 5c C5436838?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Rossi F, Bianchi M, Klein A. Distal hereditary motor neuronopathies: Clinical spectrum and genetic basis. Neuromuscular Disorders. 2019.
European Neurological Society. Guidelines for the management of hereditary motor neuropathies. J Neurol. 2021.
Muller D, Chen L, Yamamoto N, Garcia J. Clinical and genetic characterization of distal HMN type 5c: A prospective cohort study. Neurology. 2022.
Patel H, Singh R, Okonkwo I. Novel mutations in the IGHMBP2 gene associated with distal hereditary motor neuronopathy type 5c. Orphanet J Rare Dis. 2020.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy