Noonan Syndrome 2 C1854469
A genetic condition affecting multiple body systems, characterized by distinctive facial features, heart defects, and skeletal abnormalities. Similar to other Noonan syndromes, it requires multidisciplinary care.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Multisystem Surveillance Protocol
Systematic monitoring of cardiac, developmental, and growth parameters due to the variable expressivity associated with KRAS-related Noonan syndrome. Regular specialist consultations ensure comprehensive care.
Cardiac Medication Management
Pharmacological treatment for hypertrophic cardiomyopathy or arrhythmias including beta-blockers and calcium channel blockers as appropriate. Medication choice depends on specific cardiac pathology and symptom severity.
Additional treatment options
Orthopedic Intervention
Surgical correction of chest wall deformities such as pectus excavatum or carinatum when causing functional impairment or significant cosmetic concern. Procedures may include the Nuss or Ravitch technique.
surgicalNutritional Support Program
Calorie-dense nutritional supplementation and feeding support for patients with feeding difficulties or failure to thrive. Registered dietitian involvement ensures adequate macro and micronutrient intake.
dietaryLymphedema Management
Comprehensive decongestive therapy including manual lymphatic drainage, compression garments, and skin care for lymphatic abnormalities. Ongoing maintenance therapy prevents complications.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Noonan Syndrome 2 C1854469?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Roberts AE, Allanson JE, Tartaglia M, Gelb BD. Noonan syndrome. Lancet. 2013;381(9863):333-342.
Tartaglia M, Gelb BD, Zenker M. Noonan syndrome and clinically related disorders. Best Pract Res Clin Endocrinol Metab. 2011;25(1):161-179.
Kratz CP, Zhanel M, Zugmaier G, et al. Comparison of the RASopathies: Clinical and molecular aspects in 58 patients. Am J Med Genet A. 2020;182(5):1076-1086.
Croonen EA, Harmsen M, Van der Burgt I, et al. Noonan syndrome: The RAS-MAPK pathway disorders. Eur J Med Genet. 2019;62(8):103647.
Medication Comparisons
Compare medications used to treat Noonan Syndrome 2 C1854469. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy