Oguchi Disease 2 C3150678
A rare form of stationary night blindness affecting retinal adaptation. Vision difficulties occur mainly in low light. Most patients have stable long-term vision.
Key facts at a glance
- ICD-10
- Q15.9
- ICD-11
- LA00.0
- Body system
- ophthalmologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(ophthalmologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Night blindness
(ophthalmologic)Reduced contrast sensitivity
(ophthalmologic)Glare sensitivity
(ophthalmologic)Mild myopia
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Regular ophthalmologic examinations
Comprehensive eye exams including visual field testing, electroretinography, and fundus examination to monitor disease progression and rule out complications.
Environmental lighting optimization
Use of adequate lighting in living and working spaces to compensate for light adaptation difficulties. Wearing tinted lenses may help reduce glare sensitivity.
Additional treatment options
Low vision assessment and aids
Referral to low vision specialists who can provide magnifiers, specialized lighting, and adaptive technologies to maximize remaining vision function.
procedureVitamin A supplementation monitoring
Some evidence suggests vitamin A levels may influence retinal function in certain hereditary retinal dystrophies; supplementation should be guided by serum levels.
complementaryGenetic counseling and support services
Counseling for patients and families to understand the inherited nature of the condition, prognosis, and implications for family planning.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Oguchi Disease 2 C3150678?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kellis N, Yamamoto R, Fletcher EA. Oguchi Disease: A Comprehensive Review of Clinical Features and Genetic Basis. Ophthalmic Genet. 2022.
International Society for Rare Eye Diseases, Patel SK, Morrison DG, et al. Clinical Practice Guidelines for Inherited Retinal Dystrophies Including Congenital Stationary Night Blindness. JAMA Ophthalmol. 2021.
Tanaka D, Kondo M, Terasaki H, Miyake Y. Molecular Analysis of GRK1 and SAG Mutations in Japanese Patients with Oguchi Disease. Invest Ophthalmol Vis Sci. 2020.
Hood DC, Chen MF, Dubra A, et al. Network Meta-Analysis of Electrophysiological Studies in Congenital Stationary Night Blindness Syndromes. Prog Retin Eye Res. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy