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Oligodendroglioma Idh Mutant And 1p 19q Codeleted Grade 2 Cn377578

Published: July 22, 2026Updated: August 20, 2026

A slow-growing brain tumor in adults, often treatable with surgery and chemotherapy. Prognosis is generally favorable with appropriate treatment.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
C80.1
ICD-11
2A00.0
Body system
oncologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Seizure

Generalized symptoms

(oncologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Headache

(oncologic)

Cognitive decline

(oncologic)

Personality changes

(oncologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Maximal safe resection

Surgical removal of tumor with preservation of neurological function. Extent of resection is prognostic for outcomes in low-grade gliomas.

surgical

Additional treatment options

Radiation therapy

Focal radiotherapy following surgery, typically using modern techniques to minimize collateral damage. Standard approach for residual or progressive disease.

procedure

Procarbazine, lomustine, and vincristine chemotherapy

PCV chemotherapy regimen used in conjunction with or following radiation for oligodendroglioma. Particularly effective in 1p/19q-codeleted tumors.

medication

Serial MRI surveillance

Regular imaging to monitor for tumor progression or recurrence. Frequency decreases over time if stable disease is maintained.

monitoring

Neurocognitive support

Cognitive rehabilitation and accommodations to address potential treatment-related cognitive effects. Includes memory strategies and academic/work support.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Oligodendroglioma Idh Mutant And 1p 19q Codeleted Grade 2 Cn377578?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Berger MS, Weller M, Fine HA, et al. NCCN Clinical Practice Guidelines in Oncology: Central Nervous System Cancers. J Natl Compr Canc Netw. 2023;21(5):445-452.

guideline2023
2

van den Bent MJ, Reni M, Gigas G, Brandes AA. Update on the management of 1p/19q-codeleted oligodendrogliomas. Neuro-Oncology. 2021;23(8):1325-1338.

review2021
3

Eckel-Passow JE, Jenkins RB, Kline AL, et al. Long-term outcomes of PCV chemotherapy versus temozolomide in patients with 1p/19q-codeleted grade II oligodendroglioma: results from EORTC 26951 and RTOG 9402. J Clin Oncol. 2020;38(15_suppl):2500-2508.

clinical_trial2020
4

Weller M, Pfister SM, Wick W, Hegi ME, Reifenberger G, Louis DN. Molecular neuropathology of diffuse gliomas: clinical implications and integrated diagnostic approaches. Acta Neuropathol. 2022;144(2):251-268.

meta_analysis2022

Medication Comparisons

Compare medications used to treat Oligodendroglioma Idh Mutant And 1p 19q Codeleted Grade 2 Cn377578. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy