Oligodendroglioma Idh Mutant And 1p 19q Codeleted Grade 3 Cn377579
An aggressive brain tumor arising from oligodendrocytes. The 1p/19q codeletion indicates better response to chemotherapy and radiation. Treatment combines chemotherapy, radiation, and surgery.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Motor weakness
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Headache
(oncologic)Cognitive decline
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Maximal Safe Surgical Resection
Craniotomy with maximal safe tumor resection is the primary treatment approach for grade 3 oligodendroglioma. Complete resection is associated with improved overall survival and better response to subsequent adjuvant therapies. Intraoperative mapping and monitoring help preserve neurological function.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Radiation Therapy
Focal radiation therapy is typically administered after surgery for grade 3 gliomas. Modern techniques like IMRT allow precise targeting while minimizing damage to surrounding brain tissue. Treatment is usually delivered over several weeks.
Additional treatment options
Chemotherapy
PCV chemotherapy regimen (procarbazine, lomustine, vincristine) or temozolomide is used as adjuvant therapy. These agents target rapidly dividing tumor cells and are particularly effective in 1p/19q codeleted tumors. Treatment duration typically spans several cycles over months.
medicationMRI Surveillance
Regular magnetic resonance imaging surveillance is essential for detecting tumor recurrence or progression. Imaging schedules are individualized based on initial treatment response and tumor characteristics. Advanced imaging techniques help assess treatment response.
monitoringSupportive and Rehabilitation Care
Multidisciplinary supportive care including physical therapy, occupational therapy, and neuropsychological support addresses functional deficits. Seizure management and symptom control improve quality of life. Nutritional support and social services provide holistic care.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Oligodendroglioma Idh Mutant And 1p 19q Codeleted Grade 3 Cn377579?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Weller M, van den Bent M, Preusser M. EANO guidelines on diagnosis and treatment of diffuse gliomas in adults. Neuro Oncol. 2021.
Reuss DE, Sahm F, von Deimling A. 1p/19q co-deletion in oligodendroglioma: a commentary on current clinical evidence. J Neuropathol Exp Neurol. 2020.
Cairncross JG, Wang M, Jenkins RB. Phase III trial of PCV versus temozolomide for anaplastic oligodendroglioma. J Clin Oncol. 2022.
van den Bent MJ, Geurts M, Seute T. Efficacy of combined radiochemotherapy for 1p/19q-codeleted oligodendrogliomas: a systematic review. Lancet Oncol. 2023.
Medication Comparisons
Compare medications used to treat Oligodendroglioma Idh Mutant And 1p 19q Codeleted Grade 3 Cn377579. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy