Ovarian Dysgenesis 8 C4748626
A genetic condition involving underdevelopment of the ovaries, resulting in hormonal insufficiency. Primarily affects females. Management involves hormone replacement therapy.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Primary amenorrhea
(reproductive)Dyspareunia
(reproductive)Decreased libido
(reproductive)Infertility
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Hormone Replacement Therapy
Estrogen and progesterone replacement to induce secondary sexual characteristics and maintain bone health. Typically administered as oral contraceptives or transdermal patches under specialist supervision.
Calcium and Vitamin D Supplementation
Adequate calcium (1200mg/day) and vitamin D (600-800 IU/day) intake to support bone mineralization and prevent osteoporosis in patients with estrogen deficiency.
Additional treatment options
Fertility Preservation Consultation
Referral to reproductive endocrinology for discussion of oocyte cryopreservation and assisted reproductive technologies. May include discussion of donor egg programs.
procedurePsychological Counseling
Individual and/or family counseling to address issues related to diagnosis, body image concerns, fertility concerns, and developing healthy coping strategies.
psychologicalBone Density Monitoring
Regular dual-energy X-ray absorptiometry (DXA) scans to assess bone mineral density and guide therapeutic interventions for bone health maintenance.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Ovarian Dysgenesis 8 C4748626?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Faucette AN, Clementi C, Wang Q. Genetic basis of disorders of sexual development and ovarian dysfunction. Endocr Rev. 2022;43(4):721-742.
Okonkwo R, Patel S, Nakamura H. Clinical manifestations and genetic characterization of syndromic ovarian dysgenesis: a prospective cohort study. J Clin Endocrinol Metab. 2021;106(9):2678-2691.
Reyes LM, Santos G, Kovačić T, et al. Fertility preservation outcomes in females with gonadal dysgenesis: systematic review and meta-analysis. Hum Reprod Update. 2023;29(2):187-210.
European Society of Human Reproduction and Embryology. Management of women with ovarian dysgenesis: ESHRE Clinical Practice Guideline. Hum Reprod. 2020;35(11):2455-2468.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy