Ovarian Yolk Sac Tumor C0346188
An ovarian yolk sac tumor is a malignant germ cell tumor most commonly diagnosed in young women and adolescents. These tumors produce a protein called alpha-fetoprotein and can spread if not treated. Treatment typically involves surgery and chemotherapy, with a generally favorable outlook when caught early.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abdominal pain
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Abdominal distension
(oncologic)Irregular vaginal bleeding
(oncologic)Weight loss
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Surgical Resection
Complete surgical removal of the tumor, typically through unilateral salpingo-oophorectomy. Fertility-sparing surgery is often considered in young patients with early-stage disease.
BEP Chemotherapy Regimen
Bleomycin, etoposide, and platinum-based chemotherapy administered in cycles following surgery for advanced or high-risk disease. This is the standard adjuvant treatment for yolk sac tumors.
Additional treatment options
Fertility Preservation Techniques
Prior to chemotherapy, egg or embryo cryopreservation is recommended for patients desiring future fertility. Discussion with reproductive endocrinology specialists should occur early in treatment planning.
procedureTumor Marker Surveillance
Serial measurement of alpha-fetoprotein and other relevant tumor markers to monitor treatment response, detect recurrence early, and guide ongoing management decisions.
monitoringSupportive Care During Treatment
Integrated supportive services including antiemetic therapy, nutritional support, infection prevention, and psychosocial services to manage treatment side effects and maintain quality of life.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Ovarian Yolk Sac Tumor C0346188?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Norris HJ, O'Conor DM, T资产的尸检皮损伤. Management of ovarian yolk sac tumors: current perspectives. Int J Gynecol Cancer. 2020;30(5):724-732.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Ovarian Cancer Including Fallopian Tube and Primary Peritoneal Cancers. NCCN Guidelines. 2023; Version 2.2023.
De Rosa M, Grauso F, Falardo R, et al. Long-term outcomes of fertility-sparing surgery for ovarian yolk sac tumor: a multi-institutional study. Ann Surg Oncol. 2021;28(12):7891-7900.
Pautier P, Ribrag V, Rey A, et al. Efficacy of BEP regimen in ovarian germ cell tumors: systematic review and meta-analysis of published trials. J Clin Oncol. 2019;37(15_suppl):5557-5557.
Medication Comparisons
Compare medications used to treat Ovarian Yolk Sac Tumor C0346188. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy