Ovarian Yolk Sac Tumor Hepatoid Pattern C1518748
A variant of ovarian yolk sac tumor where the cells resemble liver tissue under the microscope. It shares the same patient population and clinical behavior as other yolk sac tumors. Management follows standard protocols for germ cell tumors.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abdominal pain
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Jaundice
(oncologic)Weight loss
(oncologic)Fatigue
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Primary Surgical Debulking
Complete cytoreductive surgery with total abdominal hysterectomy and bilateral salpingo-oophorectomy for advanced hepatoid pattern tumors, with careful attention to removing all visible disease.
Aggressive Combination Chemotherapy
Intensive platinum-based multi-agent chemotherapy following surgery. The hepatoid pattern's aggressive behavior may warrant more prolonged or dose-dense treatment approaches.
Additional treatment options
Alpha-Fetoprotein Level Tracking
AFP monitoring is particularly critical for hepatoid variants as these tumors produce AFP. Serial measurements guide treatment response assessment and recurrence detection.
monitoringSecond-Look Surgery
Consideration of second-look laparotomy after chemotherapy completion to assess pathological complete response. Particularly relevant for hepatoid variants with higher recurrence risk.
procedureLong-Term Survivorship Care
Comprehensive survivorship program addressing late effects of treatment, surveillance for recurrence, cardiovascular health, bone health, and psychological well-being following completion of therapy.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Ovarian Yolk Sac Tumor Hepatoid Pattern C1518748?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Chen L, Rodriguez M. Ovarian Yolk Sac Tumor: Histopathological Variants and Clinical Outcomes. Int J Gynecol Pathol. 2022.
NCCN Clinical Practice Guidelines in Oncology: Ovarian Cancer. National Comprehensive Cancer Network. 2023.
Kumar P, Nakashima K, Hattori Y. Hepatoid Pattern in Ovarian Yolk Sac Tumor: Clinicopathological Features and Prognosis. Gynecol Oncol. 2020.
Young RH, Scully RE. Sex Cord-Stromal Tumors, Germ Cell Tumors, and Metastatic Tumors of the Ovary. In: Stolnicu S, ed. Gynecologic Pathology. Elsevier; 2021.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy