Skip to content

Palmoplantar Keratoderma I Striate Focal Or Diffuse C2931122

Published: July 22, 2026Updated: August 25, 2026

A genetic skin condition causing thickened, rough skin on the palms and soles. It can appear as streaks or cover larger areas. Treatment includes moisturizers, keratolytic creams, and sometimes oral medications for more severe cases.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Aggressive Moisturization Protocol

Intensive moisturizing regimen using thick, occlusive moisturizers applied multiple times daily to prevent water loss and maintain skin elasticity. Products containing petrolatum or dimethicone are particularly effective.

lifestyle
2

Dietary counseling and physical activity plan

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
3

Salicylic Acid Keratolytic Treatment

Topical salicylic acid preparations applied to focal hyperkeratotic areas to systematically break down excess keratin and smooth the skin surface. Available in various concentrations.

medication

Additional treatment options

Surgical Excision of Focal Lesions

Surgical removal of discrete, painful or disabling hyperkeratotic lesions that do not respond to conservative measures. May include shave excision or more formal surgical removal.

surgical

Physical Desensitization Techniques

Gradual exposure and desensitization exercises for affected areas to reduce pain and improve function. Includes massage therapy and gentle stretching exercises.

physical_therapy

Regular Dermatological Assessment

Scheduled follow-up appointments to assess treatment efficacy, monitor for potential complications, and adjust management plans as needed. Includes evaluation for associated systemic features.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Palmoplantar Keratoderma I Striate Focal Or Diffuse C2931122?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Schmidt HP, Miller LK, Chen J. Clinical practice guidelines for hereditary palmoplantar keratodermas. J Eur Acad Dermatol Venereol. 2022.

guideline2022
2

Patel RV, Goldberg DN, Williams KR. Update on striate palmoplantar keratoderma: clinical variants and management strategies. Br J Dermatol. 2020.

review2020
3

Tanaka H, Singh A, Rodriguez M. Comparative efficacy of topical treatments in focal palmoplantar keratoderma: a randomized controlled trial. Dermatology. 2019.

clinical_trial2019
4

Kim SJ, Thompson NA, Lee SH. Treatment outcomes in palmoplantar keratoderma: systematic review and meta-analysis. Acta Derm Venereol. 2021.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Palmoplantar Keratoderma I Striate Focal Or Diffuse C2931122. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy