Paroxysmal Nocturnal Hemoglobinuria 2 C3809369
Another form of rare blood disorder with breakdown of red blood cells. Shares features with other types of this condition. Treatment includes complement inhibitors and supportive measures.
Key facts at a glance
- ICD-10
- D59.5
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pulmonary hypertension
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hemoglobinuria
(hematologic)Fatigue
(hematologic)Jaundice
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Terminal complement inhibition
Long-acting C5 inhibitors provide continuous complement blockade, reducing hemolysis and transfusion dependence. Represents standard of care for symptomatic PNH.
Supportive transfusion support
Regular or intermittent red blood cell transfusions to maintain adequate hemoglobin levels. Can reduce hemolytic symptoms and improve energy levels.
Additional treatment options
Regular hemolysis and hematologic monitoring
Frequent laboratory monitoring of LDH, bilirubin, haptoglobin, and CBC to assess disease activity and treatment response. Helps guide therapeutic decisions.
monitoringThrombosis prophylaxis
Anticoagulant therapy to prevent thromboembolic complications in high-risk patients or those with prior clot history. Reduces morbidity and mortality in PNH.
medicationNutritional support with iron and folate
Supplemental iron and folate to support erythropoiesis in patients with ongoing hemolysis and potential nutritional deficiencies from chronic disease.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Paroxysmal Nocturnal Hemoglobinuria 2 C3809369?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Parker C, Omine M, Richards S, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005;106(12):3699-3709.
Brodsky RA. Paroxysmal nocturnal hemoglobinuria. Blood. 2020;134(12):934-945.
Lee JW, Sicre de Fontbrune F, Wong Lee L, et al. Ravulizumab in adults with paroxysmal nocturnal hemoglobinuria: a phase 3 open-label study. Blood Adv. 2021;5(7):1820-1830.
Risitano AM, Rotoli B. Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents. Biologics. 2018;2:205-222.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy