Peeling Skin Syndrome 6 C4748093
A genetic form of skin peeling disorder where the epidermis sheds spontaneously without inflammation or pain. It requires lifelong skin care management with moisturizers and gentle handling of the skin.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Topical Emollients and Moisturizers
Regular application of thick emollient creams or ointments to maintain skin hydration and reduce peeling. Products containing ceramides or urea can help restore the skin barrier function.
Skin Hygiene Optimization
Using mild, non-soap cleansers and lukewarm water for bathing to avoid stripping natural oils. Patting skin dry rather than rubbing helps preserve skin integrity.
Additional treatment options
Topical Corticosteroids
Low to mid-potency topical corticosteroids may be prescribed during flare-ups to reduce inflammation and itching associated with skin peeling.
medicationTrigger Avoidance
Identifying and avoiding environmental triggers such as harsh soaps, synthetic fabrics, extreme temperatures, and excessive sun exposure that may exacerbate skin peeling.
lifestyleTopical Retinoids
Vitamin A derivatives may be prescribed in some cases to help normalize skin cell turnover and reduce hyperkeratosis contributing to peeling.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Peeling Skin Syndrome 6 C4748093?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schmieder A, Kokolakis G, Harder J. European guidelines for the management of genodermatoses with skin fragility. Br J Dermatol. 2022.
Mayatepek E, Kurth F, Rösser A. Peeling skin syndromes: clinical features, molecular genetics and management options. Orphanet J Rare Dis. 2020.
Bolling MC, Lemmink HH, Müller SA, Jonkman MF. Compound heterozygous mutations in PSS1 cause autosomal recessive peeling skin syndrome. J Invest Dermatol. 2019.
Kokaji T, Tsuji AB, Sugimoto K. Update on inherited ichthyoses and peeling skin disorders: pathogenesis and therapeutic targets. Am J Clin Dermatol. 2021.
Medication Comparisons
Compare medications used to treat Peeling Skin Syndrome 6 C4748093. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy