Peripheral T Cell Lymphoma C0079774
A rare cancer of the T-cells of the immune system that can affect lymph nodes, skin, and other organs. Treatment typically involves chemotherapy and sometimes targeted therapy.
Key facts at a glance
- ICD-10
- C84.40, C84.41, C84.42
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Extranodal involvement
Hypercalcemia
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Peripheral lymphadenopathy
(hematologic)B symptoms (fever, night sweats, weight loss)
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Standard Chemotherapy Regimen (CHOP)
Cyclophosphamide, doxorubicin, vincristine, and prednisone combination chemotherapy as the conventional first-line treatment for peripheral T-cell lymphoma, targeting rapidly dividing malignant lymphocytes.
CHOP Plus Novel Agent Therapy
Addition of novel agents such as pralatrexate, romidepsin, or brentuximab vedotin to CHOP-based regimens to improve response rates in aggressive PTCL subtypes.
Additional treatment options
Consolidation Autologous Stem Cell Transplant
High-dose chemotherapy followed by autologous stem cell rescue for eligible patients who achieve complete or partial remission, offering potential for durable disease control.
surgicalRadiation Therapy for Localized Disease
Involved-site radiotherapy as part of combined modality treatment for patients with limited-stage disease or for palliation of symptomatic sites in advanced cases.
procedureResponse Assessment and Surveillance Imaging
Regular PET-CT scanning and laboratory monitoring during and after treatment to assess response, detect early relapse, and guide treatment modifications.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Peripheral T Cell Lymphoma C0079774?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Horwitz SM, Ansell S, Ai WZ, et al. NCCN Guidelines Insights: T-Cell Lymphomas, Version 2.2024. J Natl Compr Canc Netw. 2024.
Vose JM, Armitage J, Weisenburger D. International T-Cell Lymphoma Project. Peripheral T-cell lymphoma, not otherwise specified: a retrospective analysis of 175 cases. Leuk Lymphoma. 2020.
Coiffier B, Pro B, Prince HM, et al. Romidepsin for the treatment of relapsed/refractory peripheral T-cell lymphoma: pivotal study results. J Clin Oncol. 2019.
Zhang JY, Briski R, Devata S, et al. Pralatrexate in relapsed or refractory peripheral T-cell lymphoma: a systematic review and meta-analysis. Blood Adv. 2021.
Medication Comparisons
Compare medications used to treat Peripheral T Cell Lymphoma C0079774. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy