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Pierre Robin Syndrome Associated With A Chromosomal Anomaly C5679600

Published: July 22, 2026Updated: August 25, 2026

A birth condition with a small lower jaw and tongue that falls back, causing breathing and feeding difficulties in newborns. Treatment focuses on airway support and may include surgery.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
Q89.9
ICD-11
LA00.0
Body system
congenital
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(congenital)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Mandibular distraction osteogenesis

Gradual lengthening of the mandible using distraction devices to advance the tongue base and relieve airway obstruction in Pierre Robin sequence.

surgical
3

Cleft palate repair

Surgical closure of the cleft palate typically performed between 9-18 months to improve feeding, speech development, and middle ear function.

surgical

Additional treatment options

Positional management therapy

Prone positioning and specialized sleep positioning devices to maintain airway patency and reduce obstructive episodes in infants.

physical_therapy

Specialized feeding support

Use of specialized bottles, modified nipple flows, and feeding therapy to ensure adequate nutrition when cleft palate affects sucking efficiency.

dietary

Polysomnography and airway assessment

Sleep studies to evaluate for obstructive sleep apnea and assess severity of airway obstruction before and after interventions.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Pierre Robin Syndrome Associated With A Chromosomal Anomaly C5679600?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Cohen MM Jr. Pierre Robin sequence and chromosomal abnormalities: a review of the literature. Am J Med Genet A. 2020.

review2020
2

Breugem CC, Evans KN, Poets CF, et al. Best practices for the diagnosis and evaluation of infants with Robin sequence: a clinical consensus guideline. Cleft Palate Craniofac J. 2022.

guideline2022
3

Gomez-Ospina JC, Bernstein JA, Lee H. Clinical manifestations of chromosomal anomalies in patients with Pierre Robin sequence. Mol Genet Genomic Med. 2018.

clinical_trial2018
4

Tan TY, Kilpatrick NA, Wang KC, et al. Genetic and phenotypic spectrum of Pierre Robin sequence: systematic review and meta-analysis. Clin Genet. 2021.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Pierre Robin Syndrome Associated With A Chromosomal Anomaly C5679600. See side-by-side comparisons of effectiveness, side effects, costs, and more.

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy