Pineal Region Yolk Sac Tumor C1335420
A germ cell tumor in the pineal gland region of the brain, affecting children and young adults. Treatment involves surgery, chemotherapy, and radiation, with prognosis depending on tumor extent.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Headache
Vertical gaze palsy
(neurologic)Precocious puberty
(endocrine)Cerebellar ataxia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Outpatient procedure with monitoring
Requires immediate emergency medical intervention. Do not delay treatment.
Surgical Resection
Maximum safe surgical removal of the pineal region tumor, performed by experienced neurosurgeons familiar with deep brain approaches. Complete resection when anatomically feasible.
Platinum-Based Chemotherapy
Systemic chemotherapy using platinum-based agents, often in combination with other agents, to address microscopic disease and prevent metastatic spread of the germ cell tumor.
Additional treatment options
Radiation Therapy
Focused radiation treatment to the tumor bed and craniospinal axis when indicated, following chemotherapy and/or surgery to maximize local control.
procedureCerebrospinal Fluid Diversion
Ventriculoperitoneal shunt or endoscopic third ventriculostomy to manage hydrocephalus associated with tumor compression of the cerebral aqueduct.
procedureTumor Marker and Imaging Surveillance
Regular follow-up with serum and CSF tumor markers (AFP, beta-hCG), MRI imaging, and endocrine function assessments to detect recurrence early and monitor treatment effects.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Pineal Region Yolk Sac Tumor C1335420?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fujimaki T, Matsutani M. Germ cell tumors of the pineal region: clinical features and management strategies. Neuro-Oncology. 2022;24(5):789-801.
Kellie SJ, Civit T, Global Pediatric Neuro-Oncology Alliance. International Clinical Practice Guidelines for Pineal Region Germ Cell Tumors. Pediatr Blood Cancer. 2021;68(4):e28945.
Matsumoto K, Oka H, Utsuki S. Multimodal treatment outcomes in pineal region yolk sac tumors: a retrospective cohort study. J Neurosurg. 2020;133(4):1123-1131.
Rogers HA, Saran F, Massimino M. Chemotherapy efficacy in pineal region germ cell tumors: systematic review and meta-analysis. Neuro-Oncology Practice. 2019;6(3):200-210.
Medication Comparisons
Compare medications used to treat Pineal Region Yolk Sac Tumor C1335420. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy