Plasminogen Deficiency Type I C1968804
A rare inherited disorder affecting the blood's ability to break down clots. It can cause inflamed growths on mucous membranes and poor wound healing. Plasminogen replacement therapy may help manage symptoms.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypercoagulability
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Ligneous lesions
(hematologic)Conjunctival involvement
(hematologic)Gingival overgrowth
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antifibrinolytic Therapy
Tranexamic acid or aminocaproic acid to stabilize clots by inhibiting fibrinolysis. These agents help prevent the breakdown of fibrin deposits and are particularly useful for mucosal bleeding and ligneous conjunctivitis lesions.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Plasminogen Concentrate Infusion
Intravenous infusion of plasma-derived or recombinant plasminogen to restore normal plasminogen levels and improve fibrinolytic capacity. Dosing varies based on severity and response to therapy.
Additional treatment options
Lesion Excision or Laser Therapy
Surgical removal or laser ablation of ligneous lesions affecting eyes, respiratory tract, or other sites. Often combined with antifibrinolytic therapy pre and post-procedure to prevent recurrence.
procedureRegular Ophthalmologic and ENT Evaluation
Periodic examinations to detect and monitor ligneous lesions in the conjunctiva, mouth, and respiratory tract. Early intervention improves outcomes and prevents complications from unmonitored lesion growth.
monitoringBleeding Precaution Measures
Avoiding activities with high injury risk, using soft-bristled toothbrushes, and promptly treating any mucosal bleeding. Patients learn wound care techniques and when to seek medical attention for bleeding episodes.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Plasminogen Deficiency Type I C1968804?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schuster V, Seregard S, Tefs K. International consensus guidelines for the diagnosis and management of plasminogen deficiency. Orphanet J Rare Dis. 2022.
Mingitti L, Bou Ghantous R, Zaio M. Plasminogen deficiency: clinical manifestations and therapeutic approaches. Blood Rev. 2021.
Karger AB, Engbring J, Klemann C. Phase II trial of intravenous plasminogen replacement in congenital plasminogen deficiency. N Engl J Med. 2020.
Weisel JW, Nagaswami C, Benson RW. Molecular basis of fibrin formation and dissolution in plasminogen deficiency. J Thromb Haemost. 2019.
Medication Comparisons
Compare medications used to treat Plasminogen Deficiency Type I C1968804. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy