Primary Biliary Cholangitis 1 C4551595
An autoimmune liver disease where the immune system attacks bile ducts, causing inflammation and liver damage. It mostly affects middle-aged women. Treatment with medication can help slow progression.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- hepatobiliary
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hepatobiliary)Generalized symptoms
(hepatobiliary)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pruritus (itching)
(hepatobiliary)Jaundice
(hepatobiliary)Xanthomas
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Ursodeoxycholic Acid (UDCA)
First-line bile acid therapy that replaces toxic bile acids and protects liver cells from damage. This treatment slows disease progression and improves liver blood tests in most patients with primary biliary cholangitis.
Alcohol Abstinence
Complete avoidance of alcohol consumption to prevent additional liver stress. Even moderate alcohol intake can accelerate liver damage in patients with compromised bile flow.
Additional treatment options
Obeticholic Acid (Second-line)
An farnesoid X receptor agonist used as add-on therapy when UDCA alone is insufficient. This medication increases bile flow and reduces bile acid toxicity in the liver.
medicationLiver-Supportive Nutrition
Emphasis on nutrient-dense whole foods while reducing saturated fat and processed food intake. Adequate protein consumption supports liver function, while limiting salt helps manage potential fluid retention.
dietaryRegular Liver Function Surveillance
Scheduled blood tests including liver enzymes, bilirubin, and alkaline phosphatase to track disease progression. Imaging and elastography may be used to assess liver fibrosis over time.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Primary Biliary Cholangitis 1 C4551595?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lindor KD, Bowlus CL, Boyer J, et al. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology. 2019.
Hirschfield GM, Gershwin ME. Primary Biliary Cirrhosis: Current and Emerging Treatment Strategies. Gastroenterology. 2023.
Nevens F, Andreone P, Mazzella G, et al. A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis. N Engl J Med. 2016.
Zhang L, Wang Y, Chen Y, et al. Comparative Efficacy of Ursodeoxycholic Acid Agents in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis. J Hepatol. 2022.
Medication Comparisons
Compare medications used to treat Primary Biliary Cholangitis 1 C4551595. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy