Primary Biliary Cholangitis 5 C3280202
An autoimmune disorder that progressively affects the liver's bile ducts. It is more common in women and may lead to serious liver complications. Treatment focuses on slowing damage and relieving symptoms.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- hepatobiliary
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Portal hypertension
Dry eyes
(hepatobiliary)Generalized symptoms
(hepatobiliary)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Generalized pruritus
(hepatobiliary)Hepatomegaly
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Ursodeoxycholic acid (UDCA)
First-line pharmacological treatment for PBC-5 variant, providing hepatoprotective effects by replacing toxic bile acids and stimulating biliary secretion. Response rates vary by disease subtype.
Disease progression monitoring
Regular assessment of liver enzymes, bilirubin, and fibrosis markers. Includes periodic imaging to evaluate for portal hypertension and hepatocellular carcinoma.
Additional treatment options
Immunosuppressive therapy
For patients with aggressive disease features, immunosuppressants may be added to reduce autoimmune-mediated liver damage. Typically used in combination with UDCA.
medicationLiver transplantation evaluation
Assessment for liver transplantation when disease progresses to advanced cirrhosis or liver failure. Transplant offers curative potential for end-stage PBC.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Primary Biliary Cholangitis 5 C3280202?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lindor KD, Bowlus CL, Boyer J, et al. Primary Biliary Cholangitis: 2023 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology. 2024.
Hirschfield GM, Gershwin ME. The immunopathogenesis of primary biliary cholangitis: a comprehensive review. Clin Rev Allergy Immunol. 2022.
Corpechot C, Chazouillères O, Belkus A, et al. Long-term effects of obeticholic acid on biochemical and clinical outcomes in patients with primary biliary cholangitis: a randomized controlled trial. J Hepatol. 2021.
Zhang L, Bao Y, Zhang H, et al. Efficacy and safety of fibrates for the treatment of primary biliary cholangitis: a systematic review and meta-analysis. Liver Int. 2020.
Medication Comparisons
Compare medications used to treat Primary Biliary Cholangitis 5 C3280202. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy