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Primary Ciliary Dyskinesia 3 C1837618

Published: July 22, 2026Updated: August 27, 2026

A genetic condition where tiny hair-like structures called cilia don't work properly, causing chronic lung infections and breathing issues. Treatment focuses on clearing airways and managing infections.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 27, 2026Editorial policy

Key facts at a glance

ICD-10
J98.9
ICD-11
CA00.0
Body system
respiratory
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Hemoptysis

Shortness of breath or cough

(respiratory)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Chronic productive cough

(respiratory)

Recurrent lower respiratory tract infections

(respiratory)

Bronchiectasis

(respiratory)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

High-frequency chest wall oscillation

Use of vest therapy or mechanical devices to provide continuous airway clearance. Effective alternative for patients who struggle with manual chest physiotherapy techniques.

physical_therapy
2

Respiratory therapy and management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Mucolytic therapy

Dornase alfa (DNase) or hypertonic saline to thin thick airway secretions, making them easier to clear through natural mucociliary action and chest physiotherapy.

medication

Additional treatment options

Nasal irrigation and sinus management

Daily saline nasal irrigation and nasal corticosteroids to manage chronic sinusitis, which is nearly universal in PCD patients due to impaired mucociliary clearance.

complementary

Inhaled corticosteroids

Anti-inflammatory therapy for patients with significant bronchial inflammation and reactive airway disease component. Reduces mucosal swelling and mucus production.

medication

Comprehensive multidisciplinary surveillance

Regular monitoring by pulmonology, otolaryngology, and fertility specialists given the multiorgan involvement in PCD including chronic sinusitis, bronchiectasis, and potential infertility.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Primary Ciliary Dyskinesia 3 C1837618?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Rubin BK, Ostrowski L, Ferkol T, et al. Primary Ciliary Dyskinesia: Diagnosis and Treatment Guidelines. Am J Respir Crit Care Med. 2022.

guideline2022
2

Horani A, Ferkol TW, Dutcher SK, et al. Genetics and Biology of Primary Ciliary Dyskinesia. Paediatr Respir Rev. 2021.

review2021
3

Knowles MR, Daniels LA, Davis SD, et al. Lung Function Outcomes in Primary Ciliary Dyskinesia: A Multicenter Study. Thorax. 2020.

clinical_trial2020
4

Gervin E, Marthin GS, Thompson R, et al. Respiratory Morbidity in Primary Ciliary Dyskinesia: Systematic Review and Meta-Analysis. Eur Respir J. 2023.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Primary Ciliary Dyskinesia 3 C1837618. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy