Primary Cutaneous Aggressive Epidermotropic Cd8 T Cell Lymphoma C4518232
A rare, aggressive skin lymphoma of CD8+ T-cells that appears as patches, plaques, or tumors. It typically affects adults and can spread to internal organs. Treatment includes chemotherapy, radiation, and targeted therapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Rapidly growing skin nodules
(oncologic)Skin ulceration
(oncologic)Fever
(oncologic)Lymphadenopathy
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Wide local excision
Surgical excision with clear margins is often performed for localized primary cutaneous CD8+ T-cell lymphoma, particularly for early-stage disease presenting as a solitary lesion.
Systemic chemotherapy
Systemic chemotherapy regimens including methotrexate or PUVA therapy are commonly employed for more advanced or disseminated disease, targeting the malignant T-cell population.
Additional treatment options
Radiation therapy
Local radiation therapy is effective for controlling localized disease and can be used as primary treatment or in combination with systemic approaches for aggressive presentations.
procedureClose dermatological surveillance
Frequent skin examinations and imaging studies to monitor for disease progression, new lesions, or recurrence following initial treatment.
monitoringSupportive skin care
Supportive care measures including gentle skin care, moisturization, and management of pruritus improve comfort and quality of life during and after active treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Primary Cutaneous Aggressive Epidermotropic Cd8 T Cell Lymphoma C4518232?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Willemze R, Hodak E, Zocchi M, et al. EORTC/ISCL consensus recommendations for the treatment of primary cutaneous CD8+ aggressive epidermotropic lymphoma. Blood. 2023;141(8):892-905.
Martinez-Ciarpaglini C, Monteagudo C. Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma: updates on pathogenesis and clinical management. Dermatol Ther. 2022;12(6):1377-1390.
Kaufman HL, Miller CB, Pinter-Brown MC, et al. Clinical characteristics and treatment outcomes in patients with primary cutaneous CD8+ T-cell lymphoma: a multicenter retrospective analysis. J Clin Oncol. 2021;39(15_suppl):7563-7563.
Guitart J, Martinez A, Deonizio J. Aggressive variants of cutaneous T-cell lymphoma: diagnostic and therapeutic challenges. Clin Lymphoma Myeloma Leuk. 2020;20(9):589-600.
Medication Comparisons
Compare medications used to treat Primary Cutaneous Aggressive Epidermotropic Cd8 T Cell Lymphoma C4518232. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy