Primary Cutaneous Cd4 Small Medium Sized Pleomorphic T Cell Lymphoma C5680503
A rare skin lymphoma made of abnormal T cells that appear small to medium-sized. It typically presents as a single skin nodule and often has a favorable outlook.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Ulcerated skin lesion
Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Skin nodule
(integumentary)Solitary skin plaque
(integumentary)Patchy skin involvement
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Topical Corticosteroids
High-potency topical corticosteroids are applied directly to skin lesions to reduce inflammation and control abnormal T-cell proliferation. This represents a first-line approach for localized disease with minimal systemic side effects.
Phototherapy (PUVA)
Psoralen plus ultraviolet A light therapy targets cutaneous lesions through photosensitization and immunosuppression. This treatment is administered in clinical settings multiple times per week for several months.
Additional treatment options
Localized Radiation Therapy
Low-dose radiation targeting individual skin lesions destroys malignant T-cells while preserving surrounding healthy tissue. This approach is particularly effective for thick or resistant plaques.
procedureOral Retinoids (Bexarotene)
Systemic retinoids normalize skin cell growth and have anti-tumor effects on cutaneous T-cells. Treatment requires monitoring of lipid levels and thyroid function throughout therapy.
medicationActive Surveillance
Regular dermatologic examinations with photography to track disease progression are appropriate for asymptomatic patients with limited lesions. Biopsies are performed if changes suggest disease progression.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Primary Cutaneous Cd4 Small Medium Sized Pleomorphic T Cell Lymphoma C5680503?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Willemze R, Hodak E, Zinzani PL, Specht L, Ladetto M. Primary cutaneous lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021;32(10):1250-1263.
Cerroni L. Cutaneous T-cell lymphomas: An illustrated review of new entities and unusual variants. J Cutan Pathol. 2020;47(2):121-135.
Bekkenk MW, Vermeer MH, Geerts ML, et al. Treatment and prognosis of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma: a series of 141 patients. Blood. 2019;133(21):2331-2338.
Kempf W, Denisjuk N, Kerl K, et al. Primary cutaneous CD4+ small to medium-sized pleomorphic T-cell lymphoma: updated therapy options. Dermatol Ther. 2022;35(6):e15489.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy