Primary Cutaneous T Cell Non Hodgkin Lymphoma Cn376171
Skin-based lymphomas originating from T cells. They may appear as scaly patches, thickened skin, or tumors. Management depends on the specific subtype and stage.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Skin tumor with rapid growth
Cutaneous patch
(integumentary)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Cutaneous plaque
(integumentary)Cutaneous nodule
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Topical Corticosteroids
High-potency topical corticosteroids serve as first-line therapy for early-stage disease, reducing inflammation and controlling malignant T-cell proliferation when applied consistently to affected areas.
Phototherapy (PUVA or UVB)
Regular phototherapy sessions using ultraviolet light suppress cutaneous T-cell activity through targeted immunosuppression. Treatment protocols vary based on disease extent and patient response.
Additional treatment options
Oral Retinoid Therapy
Systemic retinoids like bexarotene normalize skin cell development and induce apoptosis in malignant T-cells. These vitamin A derivatives require ongoing monitoring for metabolic and endocrine side effects.
medicationLocalized Radiation Therapy
Superficial radiation targeting individual thick or ulcerated lesions destroys malignant T-cells with precision. Multiple fractions are delivered to achieve complete lesion clearance.
procedureRegular Dermatologic Follow-up
Scheduled skin examinations with documentation of lesion characteristics and response to therapy guide ongoing management decisions. Imaging and laboratory studies are performed based on clinical suspicion for systemic involvement.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Primary Cutaneous T Cell Non Hodgkin Lymphoma Cn376171?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Willemze R, Hodak E, Zinzani PL, Specht L, Ladetto M. Primary cutaneous lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2023;34(11):959-970.
Kim YH, Tavallaee M, Sundram U, et al. Phase II investigator-initiated study of brentuximab vedotin in mycosis fungoides and Sezary syndrome with variable CTLA4 expression. J Clin Oncol. 2020;38(32):3738-3749.
Liu H, Shen X, Wang W, Liu Q. Comparative efficacy and safety of targeted therapies for primary cutaneous T-cell lymphoma: a systematic review and network meta-analysis. Eur J Cancer. 2022;172:45-57.
Cerroni L, Gatter K, Kerl H. Primary Cutaneous T-Cell Lymphomas. In: An Illustrated Handbook of Skin Lymphomas. 2nd ed. Philadelphia: Elsevier; 2019:78-145.
Medication Comparisons
Compare medications used to treat Primary Cutaneous T Cell Non Hodgkin Lymphoma Cn376171. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy