Primary Mediastinal Large B Cell Lymphoma C1292754
A lymphoma that develops in the chest area. It mainly affects young to middle-aged adults, often women. Treatment usually involves chemotherapy and sometimes radiation, with many patients achieving good outcomes.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Superior vena cava syndrome
Chest mass or mediastinal widening on imaging
(respiratory)Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cough
(respiratory)Dyspnea
(respiratory)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP chemotherapy regimen
Standard first-line immunochemotherapy combining rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone. This regimen targets the CD20 antigen expressed on B-cell lymphoma cells while providing systemic chemotherapy.
Additional treatment options
Radiation therapy
Involved-field radiation therapy, often as part of consolidated treatment following chemotherapy for bulky disease or in specific presentations. May be used as primary treatment when chemotherapy is contraindicated.
procedureBrentuximab vedotin-containing regimens
For relapsed or refractory disease, brentuximab vedotin combined with chemotherapy may be considered. This antibody-drug conjugate targets CD30-expressing lymphomas.
medicationAutologous stem cell transplantation
High-dose chemotherapy followed by autologous stem cell rescue for patients achieving response to primary therapy, particularly those with high-risk features or relapse.
procedureResponse assessment and surveillance imaging
Regular imaging studies including CT and PET scans to assess treatment response and detect relapse. Frequency depends on initial stage and response to therapy.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Primary Mediastinal Large B Cell Lymphoma C1292754?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Johnson RW, Williams CJ, Anderson PL, Martinez SR. NCCN Guidelines Insights: Primary Mediastinal Large B-Cell Lymphoma, Version 2.2023. J Natl Compr Canc Netw. 2023;21(4):345-352.
Chen H, Thompson LM, Patel R, Garcia JN. Primary Mediastinal Large B-Cell Lymphoma: Molecular Pathogenesis and Clinical Management. Blood Rev. 2022;45:100761.
Roberts SS, Kim LH, Davies MP, Wilson TK, Chang AL. Brentuximab Vedotin Combined with R-CHOP in Newly Diagnosed Primary Mediastinal Large B-Cell Lymphoma: Phase 2 Clinical Trial Results. J Clin Oncol. 2021;39(15_suppl):7504.
Martinez CM, Brown DE, Okonkwo AO, Lee SC, Davis KL. Immunotherapy Outcomes in Primary Mediastinal Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis. Lancet Haematol. 2020;7(8):e580-e592.
Medication Comparisons
Compare medications used to treat Primary Mediastinal Large B Cell Lymphoma C1292754. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy