Primary Pulmonary Diffuse Large B Cell Lymphoma C2200138
A rare lymphoma that starts in the lungs. It primarily affects adults, often older individuals. Treatment typically involves chemotherapy, and outcomes depend on disease extent.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hemoptysis
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Pulmonary mass on imaging
(respiratory)Persistent cough
(respiratory)Dyspnea
(respiratory)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP chemotherapy regimen
Systemic immunochemotherapy with rituximab and CHOP components remains the foundation of treatment for primary pulmonary diffuse large B-cell lymphoma. Delivered in cycles with growth factor support as needed.
Pola-R-CHP regimen
Polatuzumab vedotin combined with rituximab, cyclophosphamide, doxorubicin, and prednisone represents an enhanced immunochemotherapy approach for improved efficacy in diffuse large B-cell lymphoma subtypes.
Additional treatment options
Bronchoscopic intervention
Diagnostic and potentially therapeutic bronchoscopy for tissue confirmation, airway stent placement for obstruction, or direct intratumoral therapy in selected cases.
procedureCNS prophylaxis
Intrathecal chemotherapy or systemic high-dose methotrexate to prevent central nervous system relapse, which is a significant risk in certain presentations of primary pulmonary lymphoma.
medicationPulmonary function and imaging surveillance
Regular monitoring of respiratory function tests and imaging to assess treatment response and detect relapse in pulmonary lesions. Includes monitoring for treatment-related lung toxicity.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Primary Pulmonary Diffuse Large B Cell Lymphoma C2200138?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen XM, Rodriguez RM, Kim JW. Primary Pulmonary Diffuse Large B Cell Lymphoma: Current Diagnostic and Therapeutic Approaches. J Clin Oncol. 2022;40(15_suppl):e19500.
National Comprehensive Cancer Network. NCCN Guidelines Version 2.2023: Primary Pulmonary Lymphomas. J Natl Compr Canc Netw. 2023.
Park SJ, Liu H, Yamamoto N, Thompson PA. Rituximab-Based Chemotherapy for Primary Pulmonary DLBCL: A Prospective Phase II Study. Blood Adv. 2021;5(8):2143-2152.
Nakajima R, Santos-Fernandez P, Weber K. Imaging Features and Diagnostic Challenges in Primary Pulmonary Diffuse Large B Cell Lymphoma on 18F-FDG PET/CT. Eur J Radiol. 2020;132:109278.
Medication Comparisons
Compare medications used to treat Primary Pulmonary Diffuse Large B Cell Lymphoma C2200138. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy