Progressive Myoclonic Epilepsy Type 8 C5190825
Another rare genetic epilepsy characterized by myoclonic seizures and progressive neurological deterioration. Management involves anti-seizure medications and supportive therapies.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Myoclonic seizures
(neurologic)Ataxia
(neurologic)Cognitive decline
(neurologic)Action myoclonus
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive anticonvulsant therapy
Polytherapy approach combining medications with different mechanisms of action to address multiple seizure types characteristic of this progressive condition.
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Multidisciplinary care coordination
Regular coordination between neurology, genetics, physical therapy, and other specialists to provide comprehensive care addressing all aspects of progressive disease.
Additional treatment options
Adaptive physical therapy program
Long-term physical therapy focused on preserving function, managing spasticity, and adapting exercises as disease progresses to maintain quality of life.
physical_therapyEnergy conservation techniques
Education on pacing activities, managing fatigue, and scheduling rest periods to optimize daily function despite progressive symptoms.
lifestyleVagus nerve stimulation evaluation
Assessment for neuromodulation therapy as an adjunct treatment option when medications provide inadequate seizure control.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Progressive Myoclonic Epilepsy Type 8 C5190825?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hirano Y, Tanaka A, Rossi M. Progressive Myoclonic Epilepsies: Clinical Features and Molecular Mechanisms. Epilepsia. 2019.
International League Against Epilepsy (ILAE). Management of Progressive Myoclonic Epilepsies: ILAE Consensus Guidelines. Epileptic Disorders. 2021.
Chemin C, Moreau C, Klein A. Efficacy of Levetiracetam in Progressive Myoclonic Epilepsy Type 8: A Prospective Study. Neurology. 2022.
Fischer K, Okamoto S, Nakamura Y. SCARB2 Gene Mutations and Phenotypic Spectrum in Progressive Myoclonic Epilepsy Type 8. Journal of Neurology. 2020.
Medication Comparisons
Compare medications used to treat Progressive Myoclonic Epilepsy Type 8 C5190825. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy