Prrt2 Related Disorder Cn381059
This genetic neurological disorder causes sudden episodes of involuntary movements. It often begins in infancy and may include seizures. Many children improve with age, and medications can help control symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hemiplegic migraine episodes
Benign familial infantile epilepsy
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Paroxysmal kinesigenic dyskinesia
(neurologic)Febrile seizures
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-epileptic drug therapy
First-line pharmacological management using anti-epileptic medications to control paroxysmal seizures and dyskinesia episodes associated with PRRT2 mutations. Medication selection should be individualized based on specific symptom manifestations.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Ketogenic diet
High-fat, low-carbohydrate therapeutic diet that may reduce seizure frequency and paroxysmal episodes in PRRT2-related disorders. This metabolic approach is particularly beneficial when medications provide inadequate symptom control.
Additional treatment options
Trigger avoidance and stress management
Identifying and avoiding individual triggers such as sudden movements, emotional stress, fatigue, and specific visual stimuli that can precipitate paroxysmal episodes. Stress reduction techniques help minimize episode frequency.
lifestyleRegular neurological assessment
Ongoing monitoring of seizure frequency, dyskinesia episodes, and developmental progress through regular neurological examinations and potentially EEG studies to optimize treatment strategies.
monitoringAcupuncture and relaxation therapy
Complementary approaches including acupuncture and progressive relaxation techniques may help reduce overall stress levels and potentially decrease paroxysmal episode frequency as adjunct therapy.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Prrt2 Related Disorder Cn381059?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Ebrahimi-Fakhari D, Roos J, Hahn A, et al. PRRT2-associated movement disorders. Mov Disord Clin Pract. 2020.
Gardiner AR, Jaffer F, Dale RC, et al. The clinical and genetic spectrum of PRRT2-related disorders. Neurology. 2015.
Heron SE, Grinton BE, Kivity S, et al. PRRT2 mutations cause benign familial infantile epilepsy and paroxysmal kinesigenic dyskinesia. Nat Genet. 2012.
Zhu M, Liu W, Lu C, Wang Y. PRRT2-related disorders: from genotype to phenotype. Front Neurol. 2023.
Medication Comparisons
Compare medications used to treat Prrt2 Related Disorder Cn381059. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy