Pseudohypoaldosteronism Type 2b C1840390
Similar to Type 2a, this condition affects salt balance and causes high potassium levels. It may have additional features involving kidney function. Management includes salt replacement and careful monitoring.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hyperkalemia (elevated serum potassium)
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension (high blood pressure)
(endocrine)Hypercalciuria (elevated urinary calcium)
(endocrine)Gout (due to hyperuricemia)
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Thiazide diuretics
First-line pharmacological treatment for pseudohypoaldosteronism type 2b using thiazide diuretics to address hypertension, hyperkalemia, and the characteristic electrolyte abnormalities including hyperchloremia and metabolic acidosis.
Sodium supplementation with potassium restriction
Individualized dietary approach combining sodium supplementation when indicated with potassium restriction to maintain electrolyte balance. Specific recommendations depend on individual laboratory values and clinical presentation.
Additional treatment options
Comprehensive metabolic panel monitoring
Regular monitoring of electrolytes, acid-base status, aldosterone levels, and renal function to guide treatment adjustments and ensure optimal disease control across all organ systems affected.
monitoringFludrocortisone (in selected cases)
Mineralocorticoid replacement therapy may be considered in selected patients with significant aldosterone deficiency to help maintain electrolyte balance and blood pressure homeostasis.
medicationStress reduction and sleep optimization
Lifestyle modifications including stress management techniques, adequate sleep hygiene, and avoidance of factors that may exacerbate hypertension. These measures complement pharmacological therapy.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Pseudohypoaldosteronism Type 2b C1840390?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Khan AN, Singh G, Gupta S. Clinical practice guidelines for hereditary tubulopathies. Kidney Int Suppl. 2022.
Fujita Y, Tanaka R, Mori H. Inherited salt-wasting tubulopathies: pathophysiology and management. Pediatr Nephrol. 2021.
Wilson FH, Disse-Nicodeme S, Choate KA. Human hypertension caused by mutations in WNK kinases. N Engl J Med. 2019.
Menant M, Grimstrup C, Halbritter J. Systematic review of mineralocorticoid resistance and pseudohypoaldosteronism spectrum. Clin J Am Soc Nephrol. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy