Pseudohypoaldosteronism Type 2d C3469605
A kidney disorder causing high blood pressure and abnormal blood salt levels due to the body's resistance to aldosterone. It is managed with blood pressure medications and dietary changes.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension
(cardiovascular)Muscle weakness
(musculoskeletal)Fatigue
(general)Nephrocalcinosis
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
High sodium diet
Increased dietary sodium intake is the cornerstone of managing pseudohypoaldosteronism type 2D to compensate for renal salt wasting. Patients typically require 3-5 times normal sodium intake to maintain electrolyte balance.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Thiazide diuretics
Thiazide diuretics paradoxically improve hypertension and hyperkalemia in type 2 pseudohypoaldosteronism by enhancing renal sodium excretion while promoting potassium retention. Low doses are typically sufficient.
Additional treatment options
Potassium binders
Potassium-binding medications may be used if hyperkalemia persists despite thiazide therapy. These agents help maintain safe potassium levels in the body.
medicationElectrolyte and blood pressure monitoring
Regular monitoring of serum sodium, potassium, bicarbonate, and blood pressure is essential to guide therapy adjustments. Home blood pressure monitoring and periodic lab testing form the basis of disease management.
monitoringAvoidance of ACE inhibitors and ARBs
Patients with PHA type 2D should avoid medications that interfere with the renin-angiotensin-aldosterone system, as these can exacerbate hyperkalemia and metabolic acidosis.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Pseudohypoaldosteronism Type 2d C3469605?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wilson FH, Disse-Nicodeme S, Choate KA, et al. Human hypertension caused by mutations in WNK kinases. Science. 2001;293(5532):1107-1112.
Gordon RD. Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate. Hypertension. 1986;8(2):93-102.
Cubellis MV, Perna AE, Terrone G, et al. Pseudohypoaldosteronism type 2: Insights into the role of WNK kinases in blood pressure regulation. Nephrology Dialysis Transplantation. 2017;32(8):1317-1324.
Hadano Y, Murata Y, Yoshida K, et al. Thiazide diuretics for the treatment of pseudohypoaldosteronism type 2: Clinical and molecular characterization. Journal of Clinical Endocrinology and Metabolism. 2019;104(9):3835-3842.
Medication Comparisons
Compare medications used to treat Pseudohypoaldosteronism Type 2d C3469605. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy