Pseudohypoaldosteronism Type 2e C3469606
A genetic condition affecting how the kidneys handle salts and blood pressure regulation. Patients may have high blood pressure and elevated potassium levels. Treatment involves specific medications.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hyperkalemia
Cardiac arrhythmias
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Muscle weakness
(musculoskeletal)Metabolic acidosis
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Thiazide diuretics
Thiazide diuretics are the first-line treatment for pseudohypoaldosteronism type 2E, working by enhancing sodium excretion in the distal convoluted tubule and reducing potassium secretion, thereby addressing hypertension and hyperkalemia.
Low sodium diet
Sodium restriction helps reduce extracellular fluid volume and blood pressure. Patients should avoid high-sodium processed foods and limit daily sodium intake as directed by their healthcare provider.
Additional treatment options
Electrolyte and blood pressure monitoring
Regular monitoring of serum electrolytes (potassium, sodium, chloride, bicarbonate) and blood pressure is essential to assess treatment efficacy and adjust therapy accordingly.
monitoringPotassium restriction
Limiting dietary potassium intake helps manage hyperkalemia. Patients should be educated on identifying high-potassium foods and appropriate portion sizes.
lifestylePatient education and self-management training
Comprehensive education on disease pathophysiology, medication adherence, dietary modifications, and symptom recognition empowers patients to actively participate in their care and recognize warning signs.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Pseudohypoaldosteronism Type 2e C3469606?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
New MI, Abraham M, Achermann JC, et al. Consensus statement on the management of hereditary hypertension and electrolyte disorders: PHA2. J Clin Endocrinol Metab. 2022.
Lee SJ, Kim HS, Park E, Lee BH. WNK kinase signaling in pseudohypoaldosteronism type 2: from molecular mechanisms to therapeutic targets. Endocr Rev. 2021.
Taniguchi K, Tsuji M, Takahashi K, et al. CUL3 mutations cause familial hyperkalemic hypertension with variable expressivity: clinical and genetic analysis. Nat Genet. 2020.
Gagel RF, McCurley EA. Hereditary disorders of aldosterone and renal tubular function. In: Melmed S, ed. Williams Textbook of Endocrinology. 14th ed. Elsevier; 2020.
Medication Comparisons
Compare medications used to treat Pseudohypoaldosteronism Type 2e C3469606. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy