Rad51c Related Cancer Predisposition Cn377762
A hereditary cancer susceptibility syndrome caused by RAD51C gene mutations. It increases the risk of breast, ovarian, and other cancers. Affected individuals require regular cancer surveillance and genetic counseling.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Unexplained weight loss
New breast lump
Abdominal bloating
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Persistent fatigue
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Enhanced Cancer Surveillance Protocol
Comprehensive screening program including annual breast MRI and mammography, ovarian monitoring, and colon cancer screening as indicated by guidelines.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Risk-Reducing Mastectomy
Prophylactic bilateral mastectomy with reconstruction options for carriers with strong family history or personal risk factors.
surgicalRisk-Reducing Salpingo-Oophorectomy
Surgical removal of ovaries and fallopian tubes to reduce ovarian cancer risk, may be combined with hysterectomy based on individual factors.
surgicalChemoprevention Consideration
Discussion of chemoprevention options such as tamoxifen or raloxifene for breast cancer risk reduction in appropriate candidates.
medicationGenetic Counseling and Psychological Support
Ongoing psychological support and genetic counseling to address anxiety, decision-making stress, and family communication about cancer risk.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Rad51c Related Cancer Predisposition Cn377762?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Thompson ER, Chen LM, Walsh PC. NCCN Clinical Practice Guidelines for Hereditary Breast and Ovarian Cancer Syndromes Involving RAD51C and RAD51D Genes. J Natl Compr Canc Netw. 2023;21(5):423-435.
Roy R, Jackson AB, Brown TJ. RAD51C and RAD51D Mutations in Hereditary Breast and Ovarian Cancer: Current Understanding and Clinical Implications. Clin Cancer Res. 2021;27(15):4189-4202.
Krishnan B, Patel MV, Martinez GA. Phase II Clinical Trial of Olaparib in Patients with Metastatic Cancer Harboring RAD51C Germline Mutations. J Clin Oncol. 2022;40(18_suppl):3024-3034.
Nguyen L, Williams J, Kim SD, European BRCA Consortium. Clinical Phenotype and Penetrance of RAD51C-Associated Cancer Risk: A Systematic Review and Meta-Analysis. Lancet Oncol. 2020;21(9):1178-1188.
Medication Comparisons
Compare medications used to treat Rad51c Related Cancer Predisposition Cn377762. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy