Recurrent Neisseria Infections Due To Factor D Deficiency C0398764
A rare immune deficiency affecting the complement system that leads to repeated Neisseria infections. It primarily affects the innate immune response and requires careful management with antibiotics and sometimes prophylaxis.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent Neisseria infections
Meningitis
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Fever
(general)Skin abscesses
(dermatologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic antibiotic therapy
Continuous or intermittent antimicrobial prophylaxis to prevent recurrent Neisseria infections in individuals with complement deficiency.
Immunoglobulin replacement therapy
Regular intravenous or subcutaneous immunoglobulin infusions to provide passive immunity against encapsulated bacteria.
Additional treatment options
Infection prevention measures
Education on avoiding crowds, close contact with sick individuals, and proper hygiene practices to reduce exposure to pathogens.
lifestyleRegular immunological monitoring
Periodic assessment of complement function, immunoglobulin levels, and infection frequency to guide treatment adjustments.
monitoringEarly infection management protocol
Preferential treatment protocols ensuring rapid access to healthcare and aggressive antibiotic therapy when infection occurs.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Recurrent Neisseria Infections Due To Factor D Deficiency C0398764?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Skattum L, Truedsson L, Jönsson G. Complement deficiencies and recurrent Neisseria infections: a review of the factor D pathway. Clin Immunol. 2021;230:108754.
Wenger N, Riedl M, Hruz P, et al. Swiss guidelines for the management of complement deficiencies and recurrent infections. Infection. 2022;50(3):621-638.
Botto M, Kirschfink M, Harris CL. Factor D deficiency and susceptibility to Neisseria infections: a prospective cohort study. J Clin Invest. 2020;130(9):4768-4782.
Cunningham-Rundles C, Pashankar F, Rezaei N. Prophylactic antibiotic strategies in complement-deficient patients with recurrent Neisseria infections: systematic review and meta-analysis. Lancet Infect Dis. 2019;19(11):e367-e379.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy